PMID- 14769545
OWN - NLM
STAT- MEDLINE
DCOM- 20040415
LR  - 20061115
IS  - 1093-7404 (Print)
IS  - 1093-7404 (Linking)
VI  - 7
IP  - 2
DP  - 2004 Mar-Apr
TI  - A review of experimental studies on diesel exhaust particles and nasal epithelium 
      alterations.
PG  - 81-104
AB  - The aim of the present review is to summarize biological events in nasal 
      epithelium after short-term exposure to diesel exhaust particles (DEP). Therefore 
      human, animal, and in vitro studies carried out since 1987 are reviewed. 
      Short-term exposure results included qualitative alterations characterized by 
      immediate nasal hyperresponsiveness, antioxidant responses, marked epithelial 
      inflammation, and a specific humoral response. In addition, studies on combined 
      DEP/allergen challenge reported that, besides their intrinsic deleterious 
      properties, DEP produced adjuvant-like effects on the immediate and late-phase 
      response to allergen challenge, since they are able to mimic effects occurring 
      after allergen challenge. DEP act deeply in nasal epithelium by (1) directing 
      cytokine gene expression toward a Th2 profile, (2) enhancing local 
      antigen-specific immunoglobulin E (IgE) production, and (3) driving in vivo 
      isotype switch to IgE. Furthermore, DEP can induce in allergic subjects 
      sensitization to a neoallergen, sensitization that did not occur with exposure to 
      the neoantigen alone. Particulate pollutants such as DEP, encountered in urban 
      areas, are therefore thought to be contributing causal factors to the exaggerated 
      sensitization to allergens in subjects with appropriate genetic predisposition, 
      sensitization that they might not otherwise have experienced. These findings add 
      weight to the hypothesis that DEP are involved in the increased prevalence of 
      airway allergic diseases.
FAU - Nikasinovic, L
AU  - Nikasinovic L
AD  - Laboratoire d'Hygiene et de Sante Publique, Faculte des Sciences Pharmaceutiques 
      et Biologiques, Universite Rene Descartes, Paris, France.
FAU - Momas, I
AU  - Momas I
FAU - Just, J
AU  - Just J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Toxicol Environ Health B Crit Rev
JT  - Journal of toxicology and environmental health. Part B, Critical reviews
JID - 9802627
RN  - 0 (Allergens)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Humans
MH  - Inflammation/immunology
MH  - Nasal Mucosa/*immunology
MH  - Nasal Provocation Tests
MH  - Vehicle Emissions/*toxicity
RF  - 63
EDAT- 2004/02/11 05:00
MHDA- 2004/04/16 05:00
CRDT- 2004/02/11 05:00
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/04/16 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
AID - RKBWK4MFFADKNG0R [pii]
AID - 10.1080/10937400490241952 [doi]
PST - ppublish
SO  - J Toxicol Environ Health B Crit Rev. 2004 Mar-Apr;7(2):81-104. doi: 
      10.1080/10937400490241952.