PMID- 14769891
OWN - NLM
STAT- MEDLINE
DCOM- 20040319
LR  - 20200303
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 85
IP  - Pt 2
DP  - 2004 Feb
TI  - Absence of tumour necrosis factor facilitates primary and recurrent herpes 
      simplex virus-1 infections.
PG  - 343-347
LID - 10.1099/vir.0.19627-0 [doi]
AB  - Tumour necrosis factor (TNF) is an important cytokine in the innate immune 
      response against various infections, including herpes simplex virus (HSV) 
      infection. It has recently become a molecular target of anti-cytokine treatment 
      in certain inflammatory diseases. TNF depletion resulted in a more rapid 
      emergence of infectious HSV-1 in the explant cultures of latently infected 
      trigeminal ganglia (TG), compared with controls. To further evaluate the 
      importance of TNF in the host's defence responses against HSV-1, TNF-knockout 
      mice were challenged via scarified cornea. These mice were more susceptible to 
      primary acute corneal HSV-1 infection than controls, as manifested by an 
      increased mortality rate and higher infectious virus titres in the eyes and TG, 
      indicating that TNF is critical for defence during acute HSV infection. These 
      results imply that the administration of anti-inflammatory TNF antagonists might 
      facilitate the propagation of infectious HSV, resulting in an exacerbation of 
      primary and recurrent acute lesions.
FAU - Minagawa, Hiroko
AU  - Minagawa H
AD  - Department of Virology, Graduate School of Medical Sciences, Kyushu University, 
      Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Hashimoto, Koji
AU  - Hashimoto K
AD  - Department of Virology, Graduate School of Medical Sciences, Kyushu University, 
      Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Yanagi, Yusuke
AU  - Yanagi Y
AD  - Department of Virology, Graduate School of Medical Sciences, Kyushu University, 
      Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Corneal Diseases/*etiology/immunology/pathology
MH  - Disease Models, Animal
MH  - Disease Susceptibility/immunology
MH  - Herpes Simplex/*etiology/immunology/pathology
MH  - *Herpesvirus 1, Human
MH  - Immunity, Innate
MH  - Mice
MH  - Mice, Knockout
MH  - Organ Culture Techniques
MH  - Recurrence
MH  - Trigeminal Ganglion/virology
MH  - Tumor Necrosis Factor-alpha/*deficiency/genetics
MH  - Virus Replication/immunology
EDAT- 2004/02/11 05:00
MHDA- 2004/03/20 05:00
CRDT- 2004/02/11 05:00
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/03/20 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
AID - 10.1099/vir.0.19627-0 [doi]
PST - ppublish
SO  - J Gen Virol. 2004 Feb;85(Pt 2):343-347. doi: 10.1099/vir.0.19627-0.