PMID- 14770364
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20070413
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 20
IP  - 1
DP  - 2004 Jan
TI  - [The MMP/TIMP system in the nervous system].
PG  - 55-60
AB  - The matrix metalloproteinases (MMP) belong to a growing family of secreted or 
      membrane-bound (MT-MMP) enzymes that cleave protein components of the 
      extracellular matrix and bioactive factors involved in intercellular signaling. 
      MMP activity is counterbalanced by their four physiological inhibitors, the 
      tissue inhibitors of MMP (TIMPs). Together, MMP and TIMP control cell-cell and 
      cell-matrix interactions associated with physiological processes. However, the 
      breakdown of the protease-inhibitor balance may lead to the loss of tissue 
      homeostasis and the development of degenerative and tumorigenic processes in 
      various tissues. The emerging idea is that the MMP/TIMP system also plays a major 
      role in the pathology and physiology of the nervous system and that mastering MMP 
      activity will set the basis for new and more efficient therapeutic strategies 
      against nervous system disorders.
FAU - Rivera, Santiago
AU  - Rivera S
AD  - Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, FRE Cnrs 
      2533, Universite de la Mediterranee, Faculte de Medecine de Marseille, IFR Jean 
      Roche, boulevard Pierre Dramard, 13916 Marseille 20, France.
FAU - Jourquin, Jerome
AU  - Jourquin J
FAU - Ogier, Crystel
AU  - Ogier C
FAU - Bernard, Anne
AU  - Bernard A
FAU - Charton, Gerard
AU  - Charton G
FAU - Tremblay, Evelyne
AU  - Tremblay E
FAU - Khrestchatisky, Michel
AU  - Khrestchatisky M
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Le systeme MMP/TIMP dans le systeme nerveux.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Blood-Brain Barrier
MH  - Humans
MH  - Leukocytes/physiology
MH  - Matrix Metalloproteinases/*physiology
MH  - Nervous System/embryology/*physiopathology
MH  - Neuronal Plasticity
MH  - Permeability
MH  - Tissue Inhibitor of Metalloproteinases/*physiology
RF  - 23
EDAT- 2004/02/11 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/02/11 05:00
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
AID - 007521ar [pii]
AID - 10.1051/medsci/200420155 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2004 Jan;20(1):55-60. doi: 10.1051/medsci/200420155.