PMID- 1477191
OWN - NLM
STAT- MEDLINE
DCOM- 19930211
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 32
IP  - 12
DP  - 1992 Dec 15
TI  - Sleep EEG effects of 3,4-methylenedioxyethamphetamine (MDE; "eve") in healthy 
      volunteers.
PG  - 1108-17
AB  - 3,4-methylenedioxyethamphetamine (MDE; "Eve") exerts similar psychotropic effects 
      in humans as 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") and is less 
      toxic in animal studies. We conducted a double-blind, placebo-controlled, 
      cross-over sleep electroencephalogram (EEG) study with healthy volunteers. One 
      hundred forty milligrams of MDE or placebo were administered PO in six subjects 
      at 11 PM. Sleep EEG was registered from 11 PM-7 AM the next morning. All subjects 
      had a normal sleep onset latency. They all awoke 60 to 120 min after 
      administration of MDE and stayed awake for at least 150 min (total sleep time, 
      TST MDE < placebo and intermittent time awake MDE > placebo: p < 0.001). After 
      again falling asleep rapid eye movement (REM) sleep was totally suppressed (REM 
      during time in bed, TIB MDE < placebo: p < 0.001). A cyclic alternation of 
      relatively long periods of slow wave sleep (SWS) with periods of light sleep 
      occurred in three subjects during the second part of the night (stage 4 in second 
      part of night MDE > placebo: p = 0.16). The effects of MDE on sleep variables 
      largely demonstrate the stimulant, amphetamine-like properties of MDE.
FAU - Gouzoulis, E
AU  - Gouzoulis E
AD  - Department of Psychiatry, University of Freiburg, Germany.
FAU - Steiger, A
AU  - Steiger A
FAU - Ensslin, M
AU  - Ensslin M
FAU - Kovar, A
AU  - Kovar A
FAU - Hermle, L
AU  - Hermle L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Administration, Oral
MH  - Adult
MH  - Double-Blind Method
MH  - Electroencephalography/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polysomnography
MH  - Sleep Stages/*drug effects
MH  - Sleep, REM/drug effects
EDAT- 1992/12/15 00:00
MHDA- 1992/12/15 00:01
CRDT- 1992/12/15 00:00
PHST- 1992/12/15 00:00 [pubmed]
PHST- 1992/12/15 00:01 [medline]
PHST- 1992/12/15 00:00 [entrez]
AID - 0006-3223(92)90191-2 [pii]
AID - 10.1016/0006-3223(92)90191-2 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1992 Dec 15;32(12):1108-17. doi: 10.1016/0006-3223(92)90191-2.