PMID- 1482298
OWN - NLM
STAT- MEDLINE
DCOM- 19930209
LR  - 20131121
IS  - 0021-4884 (Print)
IS  - 0021-4884 (Linking)
VI  - 41
IP  - 10
DP  - 1992 Oct
TI  - [Involvement of allergic mechanism in minimal change nephrotic syndrome (MCNS)].
PG  - 1492-9
AB  - In this study we evaluated the involvement of allergic mechanisms in patients 
      with adult onset MCNS (17 cases) by measuring serum IgE levels and RAST scores to 
      house dust 1 (H.D.1), house dust 2 (H.D.2), Dermatophagoides farinae (D.f.), 
      Dermatophagoides ptenonyssinus (D.p.). Out of the 17 cases, three cases showed 
      high levels of IgE (more than 1000 IU/ml) and the mean level of serum IgE was 877 
      IU/ml before treatment. All cases were treated with steroid and/or 
      cyclophosphamide. After the treatment, all cases returned to remission. The level 
      of IgE decreased to the normal range in four out of seven cases which had shown 
      high levels of IgE before treatment. RAST was carried out on seven of the 17 
      cases. RAST scores for D.f. and D.f. were found to be positive in three cases, 
      but these became negative in two cases after treatment. In five cases relapsed, 
      the all cases showed to have the increased level of serum IgE and two of four 
      cases which were examined RAST score showed to have the increased RAST score for 
      D.f. and D.p. Thus, the data indicated that allergic mechanism, especially 
      against D.f. and D.p. antigen, seemed to play one of the factors in the 
      pathogenesis of MCNS.
FAU - Boku, S
AU  - Boku S
AD  - Department of Nephrology, Showa University School of Medicine.
FAU - Shinbo, H
AU  - Shinbo H
FAU - Akagi, T
AU  - Akagi T
FAU - Totsuka, D
AU  - Totsuka D
FAU - Shibata, T
AU  - Shibata T
FAU - Saito, K
AU  - Saito K
FAU - Kitazawa, K
AU  - Kitazawa K
FAU - Ito, S
AU  - Ito S
FAU - Sugisaki, T
AU  - Sugisaki T
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Arerugi
JT  - Arerugi = [Allergy]
JID - 0241212
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/*immunology
MH  - Animals
MH  - Cyclophosphamide/administration & dosage
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Methylprednisolone/administration & dosage
MH  - Middle Aged
MH  - Mites/*immunology
MH  - Nephrosis, Lipoid/drug therapy/*immunology
MH  - Radioallergosorbent Test
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
PST - ppublish
SO  - Arerugi. 1992 Oct;41(10):1492-9.