PMID- 1483059
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20180216
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 99
IP  - 1
DP  - 1992
TI  - Presence of non-Fab IgE binding molecules in the intestinal nematode parasite of 
      mice Heligmosomoides polygyrus.
PG  - 123-6
AB  - Unsuccessful attempts to identify serum parasite-specific immunoglobulin E (IgE) 
      responses in mice following infections with the intestinal nematode parasite 
      Heligmosomoides polygyrus prompted us to explore the possibility that IgE bound 
      within the parasite antigen could account for the false-positive results 
      observed. A live-worm ELISA was developed. Following incubation, irrelevant IgE 
      monoclonal antibody to DNP, IgE present in normal mouse serum, as well as IgE in 
      immune serum were independently identified within live adult worms in this H. 
      polygyrus-modified ELISA. It was concluded that in addition to parasite-specific 
      IgE binding to H. polygyrus, the parasite may attract both parasite-specific and 
      non-parasite-specific IgE via non-Fab IgE-binding molecules.
FAU - Enriquez, F J
AU  - Enriquez FJ
AD  - Hybridoma Technology, University of Arizona, Tucson 85724.
FAU - Boggavarapu, J
AU  - Boggavarapu J
FAU - Bradley-Dunlop, D
AU  - Bradley-Dunlop D
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Immunoglobulin Fab Fragments)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/immunology
MH  - Antigens, Helminth/immunology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Immunity
MH  - Immunoglobulin E/*analysis
MH  - Immunoglobulin Fab Fragments/*analysis
MH  - Intestinal Diseases, Parasitic/*immunology
MH  - Intestinal Mucosa/immunology
MH  - Mice
MH  - Nematospiroides dubius/*immunology
MH  - Strongylida Infections/*immunology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000236345 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1992;99(1):123-6. doi: 10.1159/000236345.