PMID- 1483873
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20071114
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - PRAD1 (cyclin D1): a parathyroid neoplasia gene on 11q13.
PG  - 177-80
AB  - Hyperparathyroidism is a central component of multiple endocrine neoplasia type 1 
      (MEN 1), and both sporadic and familial forms of parathyroid disease may share 
      certain pathogenetic features. We recently identified a gene that is clonally 
      rearranged with the PTH locus in a subset of sporadic parathyroid adenomas. This 
      candidate oncogene, PRAD1 (previously D11S287), appears to contribute to 
      parathyroid tumorigenesis in a fashion analogous to activation of C-MYC or BCL-2 
      by rearrangement with tissue-specific enhancers of the immunoglobulin genes in 
      B-lymphoid neoplasia. The PRAD1 gene maps to 11q13 and has been linked to the 
      BCL-1 breakpoint locus, although not to the most tightly linked MEN 1 markers, by 
      pulsed field gel electrophoresis. PRAD1 may, in fact, be the long-sought BCL-1 
      lymphoma oncogene. PRAD1 encodes a novel type of cyclin protein and thus may 
      normally function in controlling the cell cycle, perhaps through direct 
      interaction with cdc2 or a related kinase. PRAD1's possible primary, or more 
      likely secondary, involvement in the pathogenesis of MEN 1-related tumors is 
      unknown and under investigation.
FAU - Arnold, A
AU  - Arnold A
AD  - Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 
      02114.
FAU - Motokura, T
AU  - Motokura T
FAU - Bloom, T
AU  - Bloom T
FAU - Rosenberg, C
AU  - Rosenberg C
FAU - Bale, A
AU  - Bale A
FAU - Kronenberg, H
AU  - Kronenberg H
FAU - Ruderman, J
AU  - Ruderman J
FAU - Brown, M
AU  - Brown M
FAU - Kim, H G
AU  - Kim HG
LA  - eng
GR  - DK11794/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
RN  - 0 (Cyclins)
SB  - IM
GS  - PRAD1
MH  - Amino Acid Sequence
MH  - *Chromosomes, Human, Pair 11
MH  - Cyclins/genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Oncogenes/genetics
MH  - Parathyroid Neoplasms/*genetics
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):177-80.