PMID- 1486803
OWN - NLM
STAT- MEDLINE
DCOM- 19930224
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 61
IP  - 4
DP  - 1992
TI  - The human gene for oxytocin-neurophysin I (OXT) is physically mapped to 
      chromosome 20p13 by in situ hybridization.
PG  - 271-3
AB  - Two posterior pituitary hormones oxytocin and arginine-vasopressin control the 
      important activities of water excretion, parturition and lactation. Both these 
      hormones are synthesized as inactive precursors in the hypothalamus along with 
      their carrier proteins neurophysin I and neurophysin II respectively and are 
      activated upon transport to posterior pituitary. Human genes for both 
      oxytocin-neurophysin I (OXT) and arginine-vasopressin-neurophysin II (ARVP) are 
      cloned and found to be linked on chromosome 20 separated by approximately 12 kb 
      of intergenic sequences. Though OXT is not yet associated with any disease, ARVP 
      is linked to the autosomal dominant disease neurohypophyseal diabetes insipidus 
      (AD-NDI). We have mapped regionally the OXT locus to chromosome 20p13 by both 
      radioactive (ISH) and fluorescence in situ hybridization (FISH).
FAU - Rao, V V
AU  - Rao VV
AD  - Institut fur Humangenetik, Universitat Gottingen, Germany.
FAU - Loffler, C
AU  - Loffler C
FAU - Battey, J
AU  - Battey J
FAU - Hansmann, I
AU  - Hansmann I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Neurophysins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
SB  - IM
GS  - ARVP
GS  - OXT
MH  - Arginine Vasopressin/genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 20
MH  - Humans
MH  - In Situ Hybridization/methods
MH  - In Situ Hybridization, Fluorescence
MH  - Metaphase
MH  - Neurophysins/*genetics
MH  - Oxytocin/*genetics
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000133420 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1992;61(4):271-3. doi: 10.1159/000133420.