PMID- 14870891
OWN - NLM
STAT- MEDLINE
DCOM- 20040519
LR  - 20191108
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 7
IP  - 6
DP  - 2003 Dec
TI  - Adoptive immunotherapy as consolidation of remission in pediatric AML relapsing 
      post-transplant.
PG  - 446-9
AB  - Treatment of acute leukemia relapse following an allogeneic transplantation is a 
      challenge. We reinduced three pediatric patients with acute myeloid leukemia 
      (AML) relapsing after a marrow transplantation from a sibling donor into 
      remission with chemotherapy and used donor lymphocyte infusions (DLIs) as 
      consolidation. In two of the cases, the allogeneic recognition was enhanced 
      through the use of interferon in the absence of clinical graft vs. host disease 
      (GVHD). Subsequently, all the three developed (acute grade III-IV or chronic 
      extensive) GVHD and remain in remission with a good quality of life 19, 15 and 14 
      months post-relapse. We consider an active approach in the treatment of pediatric 
      AML relapsing post-transplant justified.
FAU - Vettenranta, Kim
AU  - Vettenranta K
AD  - Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for 
      Children and Adolescents, University of Helsinki, Finland. kim.vettenranta@hus.fi
FAU - Hovi, Liisa
AU  - Hovi L
FAU - Saarinen-Pihkala, Ulla M
AU  - Saarinen-Pihkala UM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
CIN - Pediatr Transplant. 2003 Dec;7(6):419-21. PMID: 14870887
MH  - Adolescent
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunotherapy, Adoptive/*methods
MH  - Leukemia, Myeloid, Acute/drug therapy/*therapy
MH  - Recurrence
MH  - Remission Induction
MH  - T-Lymphocytes/transplantation
MH  - Treatment Outcome
EDAT- 2004/02/12 05:00
MHDA- 2004/05/20 05:00
CRDT- 2004/02/12 05:00
PHST- 2004/02/12 05:00 [pubmed]
PHST- 2004/05/20 05:00 [medline]
PHST- 2004/02/12 05:00 [entrez]
AID - 10.1046/j.1399-3046.2003.00082.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2003 Dec;7(6):446-9. doi: 10.1046/j.1399-3046.2003.00082.x.