PMID- 14872175
OWN - NLM
STAT- MEDLINE
DCOM- 20040311
LR  - 20071115
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 23
IP  - 2
DP  - 2004 Feb
TI  - Cerebrospinal fluid and plasma concentrations of proinflammatory mediators in 
      human immunodeficiency virus-infected children.
PG  - 114-8
AB  - BACKGROUND: The pathogenesis of HIV encephalopathy is poorly understood 
      especially in children. Studies suggest that HIV replication and the release of 
      proinflammatory mediators in the central nervous system contribute to the 
      pathogenesis of HIV dementia in adults. METHODS: Cerebrospinal fluid (CSF) and 
      plasma samples from 23 HIV-infected children were longitudinally analyzed at 
      Weeks 0, 8, 16 and 48 for HIV RNA and concentrations of the following 
      proinflammatory mediators: monocyte chemotactic protein-1 (MCP-1), tumor necrosis 
      factor-alpha, regulated upon activation, normal T cell expressed and secreted 
      (RANTES), macrophage-inflammatory protein (MIP)-1-alpha, MIP-1-beta and matrix 
      metalloproteinase-9 (MMP-9). RESULTS: All 23 children had detectable 
      concentrations of MCP-1 in the CSF at all time points evaluated. However, of the 
      remaining of proinflammatory mediators measured in CSF at baseline, only a few 
      children had detectable concentrations: tumor necrosis factor-alpha, n = 1; 
      RANTES, n = 5; MMP-9, n = 9; MIP-1-alpha and MIP-1-beta, n = 0. A reduction from 
      baseline to Week 48 was observed in CSF concentrations of MCP-1 and, among 
      children with detectable values, MMP-9, which paralleled declines in CSF HIV RNA. 
      CONCLUSION: These results suggest that MCP-1 and MMP-9 may be involved in the 
      pathogenesis of central nervous system disease in HIV-infected children.
FAU - McCoig, Cynthia
AU  - McCoig C
AD  - Department of Pediatrics, University of Texas Southwestern Medical Center, 
      Dallas, TX, USA.
FAU - Castrejon, Maria Mercedes
AU  - Castrejon MM
FAU - Saavedra-Lozano, Jesus
AU  - Saavedra-Lozano J
FAU - Castano, Elizabeth
AU  - Castano E
FAU - Baez, Carmen
AU  - Baez C
FAU - Lanier, E Randall
AU  - Lanier ER
FAU - Saez-Llorens, Xavier
AU  - Saez-Llorens X
FAU - Ramilo, Octavio
AU  - Ramilo O
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Inflammation Mediators)
RN  - 0 (RNA, Viral)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - AIDS Dementia Complex/blood/cerebrospinal fluid/*diagnosis/drug therapy
MH  - Anti-HIV Agents/*administration & dosage
MH  - Chemokine CCL2/blood/cerebrospinal fluid
MH  - Chemokine CCL5/cerebrospinal fluid
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Infant
MH  - Inflammation Mediators/*blood/*cerebrospinal fluid
MH  - Male
MH  - Matrix Metalloproteinase 9/analysis/blood/cerebrospinal fluid
MH  - Probability
MH  - Prognosis
MH  - RNA, Viral/analysis
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - *Viral Load
MH  - Virus Replication/drug effects
EDAT- 2004/02/12 05:00
MHDA- 2004/03/12 05:00
CRDT- 2004/02/12 05:00
PHST- 2004/02/12 05:00 [pubmed]
PHST- 2004/03/12 05:00 [medline]
PHST- 2004/02/12 05:00 [entrez]
AID - 00006454-200402000-00005 [pii]
AID - 10.1097/01.inf.0000109247.67480.7a [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2004 Feb;23(2):114-8. doi: 
      10.1097/01.inf.0000109247.67480.7a.