PMID- 1487616
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 16
IP  - 3
DP  - 1992 Nov
TI  - Tumor necrosis factor-alpha in liver transplantation and resection. No evidence 
      for a key role in ischemia-reperfusion injury.
PG  - 376-9
AB  - Experimental studies have shown that liver ischemia-reperfusion induces Kupffer 
      cell activation and tumor necrosis factor-alpha (TNF alpha) release. The aim of 
      this work was to determine whether severe hepatic ischemia and subsequent 
      reperfusion triggers TNF alpha release in man. Serum TNF alpha was measured 
      before and 3, 10, 30, 60, 120 min after revascularization and postoperatively at 
      day 1 and 2 in 11 patients with orthotopic liver transplantation (group 1) and 4 
      patients with liver resection with vascular occlusion (group 2). In group 1, TNF 
      alpha levels decreased during the first few minutes of reperfusion, then 
      increased slightly to peak at 120 min (40 +/- 13 pg/ml). Primary non-function 
      occurred in 1 patient in whom low peroperative levels of TNF alpha levels were 
      measured. In group 2, no significant changes in TNF alpha levels were observed. 
      These data, in a small number of patients: (a) show that hepatic 
      ischemia-reperfusion does not result in major TNF alpha production; (b) do not 
      support a primary pathogenic role for TNF alpha in damage after 
      ischemia-reperfusion in humans.
FAU - Chazouilleres, O
AU  - Chazouilleres O
AD  - Unite d'Hepatologie, Hopital Saint Antoine, Paris, France.
FAU - Guechot, J
AU  - Guechot J
FAU - Balladur, P
AU  - Balladur P
FAU - Masini, J P
AU  - Masini JP
FAU - Delva, E
AU  - Delva E
FAU - Laribi, A
AU  - Laribi A
FAU - Giboudeau, J
AU  - Giboudeau J
FAU - Lienhart, A
AU  - Lienhart A
FAU - Parc, R
AU  - Parc R
FAU - Poupon, R
AU  - Poupon R
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - Liver/*blood supply/metabolism/*surgery
MH  - Liver Transplantation/*physiology
MH  - Reperfusion Injury/*metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - S0168-8278(05)80673-7 [pii]
AID - 10.1016/s0168-8278(05)80673-7 [doi]
PST - ppublish
SO  - J Hepatol. 1992 Nov;16(3):376-9. doi: 10.1016/s0168-8278(05)80673-7.