PMID- 1488961
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20190509
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 136
IP  - 11
DP  - 1992 Dec 1
TI  - Markers of health status in an HTLV-I-positive cohort.
PG  - 1349-57
AB  - The health effects of chronic human T-cell lymphotropic virus type I (HTLV-I) 
      infection were examined in a cohort of Japanese men who had emigrated from 
      Okinawa, Japan, and had been participants in a prospective study in Hawaii since 
      1965. In the present follow-up study carried out in 1987-1988, various health 
      indicators were measured in the subjects, whose mean age was 72.5 years. 
      Participation rates were lower in the HTLV-I seropositives than in the 
      seronegatives (46.7% vs. 76.0%) in the > or = 75-year age group. Lack of 
      participation was significantly correlated with a high HTLV-I antibody titer. 
      Among the participants, seropositive subjects were significantly more likely than 
      the seronegatives to have lymphocytopenia (32.7% vs. 17.7%) and mild anemia 
      (25.5% vs. 14.1%) after adjustment for age and socioeconomic status. The 
      seropositives also had a higher frequency of acupuncture therapy (age-adjusted 
      odds ratios were 2.1 and 4.2 for 1-5 treatments and > or = 6 treatments, 
      respectively). Proportions of subjects who had been hospitalized at least twice 
      were higher among the seropositives in the oldest age groups, 70-74 years and > 
      or = 75 years, but not in those aged 65-69 years. Although specific disease 
      conditions were not identified in this study, hematologic data, treatment 
      histories, and the correlation between participation status and HTLV-I antibody 
      titers suggest that chronic HTLV-I infection may be associated with as yet 
      undefined adverse health effects, particularly in older age groups.
FAU - Ho, G Y
AU  - Ho GY
AD  - Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins 
      University, Baltimore, MD.
FAU - Nelson, K
AU  - Nelson K
FAU - Nomura, A M
AU  - Nomura AM
FAU - Polk, B F
AU  - Polk BF
FAU - Blattner, W A
AU  - Blattner WA
LA  - eng
GR  - N01 CP-EB-51023-21/CP/NCI NIH HHS/United States
GR  - R01-CA-33644/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Acupuncture Therapy/statistics & numerical data
MH  - Age Factors
MH  - Aged
MH  - Anemia/*epidemiology/etiology
MH  - Antibodies, Viral/blood
MH  - Blood Cell Count
MH  - Educational Status
MH  - *Emigration and Immigration
MH  - Follow-Up Studies
MH  - HTLV-I Infections/blood/complications/*epidemiology
MH  - Hawaii/epidemiology
MH  - *Health Status Indicators
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Japan/ethnology
MH  - Lymphopenia/*epidemiology/etiology
MH  - Male
MH  - Marital Status
MH  - Patient Participation
MH  - Prospective Studies
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Socioeconomic Factors
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.aje.a116447 [doi]
PST - ppublish
SO  - Am J Epidemiol. 1992 Dec 1;136(11):1349-57. doi: 
      10.1093/oxfordjournals.aje.a116447.