PMID- 1491705
OWN - NLM
STAT- MEDLINE
DCOM- 19930302
LR  - 20201209
IS  - 0026-9298 (Print)
IS  - 0026-9298 (Linking)
VI  - 140
IP  - 12
DP  - 1992 Dec
TI  - [Effectiveness of Haemophilus influenzae B-diphtheria conjugate vaccination in 
      German children].
PG  - 852-6
AB  - BACKGROUND: In 1990 the Haemophilus influenzae b-Diphtheria conjugate vaccine 
      (Hib-D) was introduced in Germany. In addition, most children under 18 months of 
      age failed to develop protective levels of Hib antibodies in response to systemic 
      infections. METHODS: To evaluate the protective efficacy of the Hib-D vaccine in 
      Germany a post marketing case-control study was performed during 1.5. 1990-30.4. 
      1992. Surveillance for invasive Hib-infections was maintained by pediatricians of 
      8 hospitals in the Rhein-Main area. The antibody responses to Hib were evaluated 
      by ELISA at the onset (days 0-3) and during remission of disease. RESULTS: During 
      the first year of the study 23 cases per 100,000 children of invasive 
      Hib-infections were recorded. Of these children, 15 suffered from meningitis, 6 
      from epiglottitis and one from cellulitis and pericarditis respectively. None of 
      these patients had been vaccinated except for one, who received two injections of 
      Hib-D. Due to increased acceptance of the Hib-D vaccine we found a significant 
      reduction of invasive Hib-infections (6 cases per 100,000 children) in the second 
      year of the study. Again, of these children only one child was vaccinated. As 
      expected, in all patients investigated the initial Hib antibody level was below 1 
      microgram/ml. The development of Hib specific immunity to invasive disease was 
      clearly age dependent: 10 of 11 children below 18 months failed to produce any 
      Hib antibodies (> 0.15 microgram/ml) in response to their infection. In contrast 
      8 of 10 children older than 18 months developed protective antibody levels to 
      Hib. CONCLUSIONS: The incidence of serious Hib-disease has significantly 
      decreased in Germany since the introduction of the Hib-D vaccine. Because no 
      other Hib vaccine was licensed in Germany our data confirm efficacy and safety of 
      Hib-D reported previously. In addition, children, who contracted disease before 
      18 months of age, remain susceptible to Hib and require active immunization for 
      protection.
FAU - Zielen, S
AU  - Zielen S
AD  - Zentrum der Kinderheilkunde, Universitat Frankfurt/Main.
FAU - Scheurer, J
AU  - Scheurer J
FAU - Rhodius, U
AU  - Rhodius U
FAU - Schafer, V
AU  - Schafer V
FAU - Isenberg, H
AU  - Isenberg H
FAU - Bauscher, P
AU  - Bauscher P
FAU - Schroder, S
AU  - Schroder S
FAU - Ahrens, P
AU  - Ahrens P
FAU - Hofmann, D
AU  - Hofmann D
LA  - ger
PT  - Journal Article
TT  - Untersuchung zur Effektivitat der 
      Haemophilus-influenzae-B-Diphtherie-Konjugatimpfung bei deutschen Kindern.
PL  - Germany
TA  - Monatsschr Kinderheilkd
JT  - Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur 
      Kinderheilkunde
JID - 8206462
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Diphtheria Toxoid)
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid 
      conjugate)
SB  - IM
MH  - Antibodies, Bacterial/*analysis
MH  - Bacterial Vaccines/*administration & dosage/adverse effects/immunology
MH  - Child
MH  - Child, Preschool
MH  - Diphtheria Toxoid/*administration & dosage/adverse effects/immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Germany
MH  - *Haemophilus Vaccines
MH  - Haemophilus influenzae/*immunology
MH  - Humans
MH  - Immunity, Active/immunology
MH  - Immunization Schedule
MH  - Infant
MH  - Male
MH  - Meningitis, Haemophilus/*immunology/prevention & control
MH  - Prospective Studies
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
PST - ppublish
SO  - Monatsschr Kinderheilkd. 1992 Dec;140(12):852-6.