PMID- 1493542
OWN - NLM
STAT- MEDLINE
DCOM- 19930305
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 599
IP  - 1
DP  - 1992 Dec 18
TI  - Influence of trigeminal nasal afferents on bulbar respiratory neuronal activity.
PG  - 105-16
AB  - This study examined the influence of nasal trigeminal afferents, the anterior 
      ethmoidal nerve (AEN) and posterior nasal nerves (PNN) on the spike discharges of 
      respiratory-related neurons recorded in the ventral respiratory group (VRG) 
      (2.6-3.5 mm lateral to the midline, from 1 mm rostral to 3 mm caudal to the obex 
      and at depth of 2-4 mm below the dorsal surface). Electrical stimulations to the 
      AEN and PNN were administered to 10 pentobarbital anaesthetized cats and to 8 
      ketamine anaesthetized, vagotomized, curarized and ventilated cats. Single shock 
      stimulations of either nerve evoked transient and total inhibition of inspiratory 
      activities. Expiratory-related neurons of the VRG presented three patterns of 
      activity in response to stimulation:excitation, inhibition or inhibition followed 
      by excitation. More generally, expiratory units are activated with a short 
      latency. In the course of repetitive stimulation of the AEN and PNN we observed a 
      prolongation of the spontaneous inspiratory discharge which presented transient, 
      short inhibition in response to each shock. Most expiratory units presented a 
      short activation which was synchronous with the transient inhibition of 
      inspiratory activities. When repetitive stimulation provoked a sneeze-like 
      response, we observed a progressive increase in the duration of transient 
      inspiratory inhibition first, associated with a progressive reinforcement of 
      transient expiratory activation. Secondarily, just before the expiratory thrust, 
      we noted a stronger inhibition of the inspiratory activity which preceded a 
      high-frequency (400 Hz) expiratory discharge. Nasal afferents exert a forceful 
      excitatory effect on bulbospinal (BS) and non-bulbospinal-non-vagal (NBS-NV) 
      expiratory cells of the VRG. The effects due to vagotomy and curarization are 
      discussed.
FAU - Wallois, F
AU  - Wallois F
AD  - CNRS URA 1331, UFR de medecine, Amiens France.
FAU - Macron, J M
AU  - Macron JM
FAU - Jounieaux, V
AU  - Jounieaux V
FAU - Duron, B
AU  - Duron B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 690G0D6V8H (Ketamine)
RN  - I4744080IR (Pentobarbital)
SB  - IM
MH  - Action Potentials
MH  - Afferent Pathways/*physiology
MH  - Animals
MH  - Cats
MH  - Electric Stimulation
MH  - Female
MH  - Inhalation/drug effects
MH  - Ketamine/pharmacology
MH  - Male
MH  - Medulla Oblongata/*physiology
MH  - Neurons/*physiology
MH  - Nose/*innervation
MH  - Olfactory Bulb/*physiology
MH  - Pentobarbital/pharmacology
MH  - Phrenic Nerve/drug effects/physiology
MH  - Respiration/drug effects/*physiology
MH  - Trigeminal Nerve/*physiology
MH  - Vagus Nerve/physiology
EDAT- 1992/12/18 00:00
MHDA- 1992/12/18 00:01
CRDT- 1992/12/18 00:00
PHST- 1992/12/18 00:00 [pubmed]
PHST- 1992/12/18 00:01 [medline]
PHST- 1992/12/18 00:00 [entrez]
AID - 0006-8993(92)90857-6 [pii]
AID - 10.1016/0006-8993(92)90857-6 [doi]
PST - ppublish
SO  - Brain Res. 1992 Dec 18;599(1):105-16. doi: 10.1016/0006-8993(92)90857-6.