PMID- 1493593
OWN - NLM
STAT- MEDLINE
DCOM- 19930311
LR  - 20190720
IS  - 0008-4212 (Print)
IS  - 0008-4212 (Linking)
VI  - 70
IP  - 9
DP  - 1992 Sep
TI  - Influence of chronic nadolol treatment on blood pressure and vascular changes in 
      spontaneously hypertensive rats.
PG  - 1261-70
AB  - Chronic treatment of spontaneously hypertensive rats (SHR) and Kyoto-Wistar 
      normotensive rats (WKY) with nadolol was carried out from gestation until 28 
      weeks of age. Nadolol treatment caused some lowering of blood pressure but did 
      not prevent the development of hypertension or cardiac hypertrophy in the SHR, in 
      spite of significant beta-blockade. The lumen of large mesenteric arteries from 
      control SHR was smaller than from WKY, and nadolol treatment increased the lumen 
      size in the SHR. An increased number of smooth muscle cell layers present in the 
      control SHR as compared with WKY was reduced slightly by nadolol treatment. 
      However, the changes produced by nadolol did not reach the levels of control and 
      treated WKY. In the aorta, the incidence of polyploid smooth muscle cells was 
      higher in the SHR than the WKY in the control group. Nadolol treatment reduced 
      the percentage of polyploid cells in both SHR and WKY, so that the difference 
      between these two groups of animals was eliminated in the treated groups. The 
      tissue level of norepinephrine in the plasma, heart, mesenteric arteries, and 
      adrenal glands in the SHR and WKY was not affected by the treatment. We suggest 
      that the ineffectiveness of nadolol in preventing hypertension development may be 
      due to its lack of effect in preventing primary changes in the resistance 
      arteries, and that the development of polyploidy of smooth muscle cells may be 
      mediated by beta-receptors.
FAU - Lee, R M
AU  - Lee RM
AD  - Smooth Muscle Research Programme, McMaster University, Hamilton, Ont., Canada.
FAU - Tsoporis, J
AU  - Tsoporis J
FAU - Wang, R R
AU  - Wang RR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 42200-33-9 (Nadolol)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenal Glands/metabolism
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Body Weight/drug effects
MH  - Female
MH  - Hypertension/*drug therapy/prevention & control
MH  - Male
MH  - Mesenteric Arteries/anatomy & histology/*drug effects/metabolism
MH  - Nadolol/*pharmacology
MH  - Norepinephrine/blood/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1139/y92-175 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 1992 Sep;70(9):1261-70. doi: 10.1139/y92-175.