PMID- 1494907
OWN - NLM
STAT- MEDLINE
DCOM- 19920909
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 59
IP  - 3
DP  - 1992 Sep
TI  - Interleukin 1 and tumor necrosis factor-alpha stimulate the production of 
      colony-stimulating factor 1 by murine astrocytes.
PG  - 1183-6
AB  - Astrocytes have the ability to secrete colony-stimulating factor 1 (CSF-1), a 
      growth factor known to stimulate the proliferation of brain macrophages. We have 
      studied the effect of cytokines such as interleukin 1 (IL-1), tumor necrosis 
      factor-alpha (TNF alpha), and interleukin 6 (IL-6) on the production of CSF-1 by 
      cultured primary astrocytes and an astrocytic cell line derived from embryonic 
      mouse brain. We observed that both TNF alpha and IL-1 increased CSF-1 mRNA and 
      protein levels in the astrocytic cultures. In contrast, IL-6 was ineffective. The 
      CSF-1 mRNA levels were strongly reduced by incubating immortalized astrocytic 
      cells with staurosporine, a protein kinase C inhibitor, both in the absence and 
      in the presence of cytokines. Conversely, 12-O-tetradecanoylphorbol 13-acetate, a 
      protein kinase C activator, increased CSF-1 mRNA levels. These results suggest a 
      mechanism whereby mononuclear phagocytes could favor their own recruitment in the 
      CNS by producing cytokines.
FAU - Thery, C
AU  - Thery C
AD  - INSERM U. 114, Chaire de Neuropharmacologie, College de France, Paris.
FAU - Stanley, E R
AU  - Stanley ER
FAU - Mallat, M
AU  - Mallat M
LA  - eng
GR  - CA 32551/CA/NCI NIH HHS/United States
GR  - P30-CA 1330/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Cells, Cultured
MH  - Interleukin-1/*pharmacology
MH  - Interleukin-6/pharmacology
MH  - Macrophage Colony-Stimulating Factor/*biosynthesis
MH  - Mice
MH  - Protein Kinase Inhibitors
MH  - Protein Kinases/physiology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1992.tb08366.x [doi]
PST - ppublish
SO  - J Neurochem. 1992 Sep;59(3):1183-6. doi: 10.1111/j.1471-4159.1992.tb08366.x.