PMID- 14963351
OWN - NLM
STAT- MEDLINE
DCOM- 20040803
LR  - 20061115
IS  - 0042-1138 (Print)
IS  - 0042-1138 (Linking)
VI  - 72
IP  - 2
DP  - 2004
TI  - Examination of tumorigenesis of precursor lesions in bladder cancer by in situ 
      hybridization.
PG  - 118-22
AB  - Through examinations using fluorescence in situ hybridization (FISH) of 
      chromosomes 1 and 9, we tried to obtain more information on dysplasia and 
      carcinoma in situ (Cis) in relation to the oncogenesis of bladder cancer. 63 
      paraffin sections (dysplasia grades I-III and Cis) were evaluated, and 8 negative 
      sections functioned as a control group. For FISH, DNA samples of CEP 1 and 9 
      (alpha satellites) were chosen. Gains (aneuploidy) or losses (monosomy) of 
      chromosomal material were determined microscopically. Dysplasia grades I-III 
      showed a 5-18% aberration in chromosome 1 aneuploidy and a 19-29% aberration in 
      monosomy 9. Cis revealed 27% aneuploidy of chromosomes 1 and 9. Although at 
      present dysplasia grade III and Cis of the bladder are viewed as 
      histopathologically identical, we examined both molecular genetic differences in 
      chromosome 9. As referred to in the literature we found the same genetic 
      aberrations for dysplasias (grades I-III) and noninvasive papillary bladder 
      tumors as well as for Cis and solid invasive bladder cancer.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Krause, Steffen
AU  - Krause S
AD  - Department of Urology, Friedrich Alexander University, Erlangen-Nurnberg, 
      Germany. frens.steffen.krause@t-online.de
FAU - Feil, Gerhard
AU  - Feil G
FAU - Beiter, Thomas
AU  - Beiter T
FAU - Pressler, Harald
AU  - Pressler H
FAU - Schrott, Karl M
AU  - Schrott KM
FAU - Bichler, Karl-Horst
AU  - Bichler KH
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Urol Int
JT  - Urologia internationalis
JID - 0417373
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneuploidy
MH  - Carcinoma in Situ/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Urinary Bladder/pathology
MH  - Urinary Bladder Neoplasms/*genetics/pathology
EDAT- 2004/02/14 05:00
MHDA- 2004/08/04 05:00
CRDT- 2004/02/14 05:00
PHST- 2003/07/02 00:00 [received]
PHST- 2003/09/19 00:00 [accepted]
PHST- 2004/02/14 05:00 [pubmed]
PHST- 2004/08/04 05:00 [medline]
PHST- 2004/02/14 05:00 [entrez]
AID - 75964 [pii]
AID - 10.1159/000075964 [doi]
PST - ppublish
SO  - Urol Int. 2004;72(2):118-22. doi: 10.1159/000075964.