PMID- 14967317
OWN - NLM
STAT- MEDLINE
DCOM- 20040914
LR  - 20041117
IS  - 0966-3274 (Print)
IS  - 0966-3274 (Linking)
VI  - 12
IP  - 2
DP  - 2004 Jan
TI  - Panel reactive antibody positivity and associated HLA antibodies in Turkish renal 
      transplant candidates.
PG  - 185-8
AB  - Pre- and post-renal transplantation panel reactive antibody (PRA) screening is 
      associated with increased incidence of hyperacute or acute graft rejection and 
      graft loss. This study was designed to find any relationship PRA sensitization 
      and associated human leukocyte antigen (HLA)-specific antibodies in Turkish renal 
      transplant candidates. We included 340 patients who were in the renal 
      transplantation waiting list in the study. We determined PRA sensitization ratio 
      and the associated anti-HLA IgG antibody distribution of the patient group. The 
      PRA testing was currently performed and levels above 30% were accepted to be 
      positive. The PRA class I positivity was determined in 24 (7%) and class II in 34 
      (10%) of the patients. The most frequent HLA antibodies for class I were B56, A2, 
      A34, A1, A23, A24 and B61; and for class II were DR11, DR14, DQ7, DR10, DQ5, DR1 
      and DR7, respectively. From these, the increase of the numbers of anti-HLA class 
      II antibodies was significantly correlated with the increase of PRA sensitization 
      ratio. In conclusion, the identification of the associated HLA-specific 
      antibodies and correlation with the Turkish population HLA antigen distribution 
      will identify the high-risk patients who are candidates for transplantation.
FAU - Ozdemir, Fatma Nurhan
AU  - Ozdemir FN
AD  - Department of Nephrology, Baskent University School of Medicine, Ankara, Turkey.
FAU - Sezer, Siren
AU  - Sezer S
FAU - Akcay, Ali
AU  - Akcay A
FAU - Arat, Zubeyde
AU  - Arat Z
FAU - Turan, Munire
AU  - Turan M
FAU - Gulmus, Sale
AU  - Gulmus S
FAU - Kulah, Eyup
AU  - Kulah E
FAU - Haberal, Mehmet
AU  - Haberal M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Turkey
EDAT- 2004/02/18 05:00
MHDA- 2004/09/15 05:00
CRDT- 2004/02/18 05:00
PHST- 2003/09/10 00:00 [received]
PHST- 2003/11/18 00:00 [revised]
PHST- 2003/11/21 00:00 [accepted]
PHST- 2004/02/18 05:00 [pubmed]
PHST- 2004/09/15 05:00 [medline]
PHST- 2004/02/18 05:00 [entrez]
AID - S0966-3274(03)00100-X [pii]
AID - 10.1016/j.trim.2003.11.003 [doi]
PST - ppublish
SO  - Transpl Immunol. 2004 Jan;12(2):185-8. doi: 10.1016/j.trim.2003.11.003.