PMID- 14967790
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20220408
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 140
IP  - 2
DP  - 2004 Feb
TI  - Association between anticonvulsant hypersensitivity syndrome and human 
      herpesvirus 6 reactivation and hypogammaglobulinemia.
PG  - 183-8
AB  - BACKGROUND: Anticonvulsant hypersensitivity syndrome (AHS) is a life-threatening, 
      drug-induced, multiorgan system reaction. The identification of predisposing 
      factors is clearly needed to predict the incidence and outcome of AHS; attention 
      has recently been focused on reactivation of human herpesvirus 6 (HHV-6). 
      OBJECTIVE: To determine whether immunosuppressive conditions that can allow HHV-6 
      reactivation could be specifically detected in association with the onset of AHS. 
      DESIGN: We analyzed patients with AHS who were treated during 1997-2002. Two 
      groups of patients receiving anticonvulsants served as controls. SETTING: 
      Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan. 
      Patients Ten patients with AHS. MAIN OUTCOME MEASURES: The results of serologic 
      tests for antibody titers for various viruses, including HHV-6, HHV-6 DNA 
      detection by real-time polymerase chain reaction, immunoglobulin levels by 
      turbidimetric immunoassay, IgG subclass levels by nephelometry, and CD19(+) 
      B-cell counts by flow cytometric analysis, were sequentially assessed. RESULTS: 
      Serum IgG levels (mean, 745 mg/dL) and circulating B-cell counts (mean, 88/ micro 
      L) in patients with AHS were significantly decreased at onset compared with 
      control groups (P<.001 and P =.007, respectively). These alterations returned to 
      normal on full recovery. Reactivation of HHV-6 as judged by a greater than 4-fold 
      increase in HHV-6 IgG titers was exclusively detected in most patients with AHS 
      associated with decreased IgG levels and B-cell counts. CONCLUSIONS: A decrease 
      in immunoglobulin levels and B-cell counts can be associated with HHV-6 
      reactivation and the subsequent onset of AHS. These immunological alterations 
      might be a useful predictor of the development of AHS.
FAU - Kano, Yoko
AU  - Kano Y
AD  - Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
FAU - Inaoka, Miyuki
AU  - Inaoka M
FAU - Shiohara, Tetsuo
AU  - Shiohara T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Antibodies, Viral)
RN  - 0 (Anticonvulsants)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulins)
SB  - IM
CIN - Arch Dermatol. 2004 Feb;140(2):226-30. PMID: 14967800
MH  - Adult
MH  - Agammaglobulinemia/complications
MH  - Aged
MH  - Antibodies, Viral/*blood
MH  - Anticonvulsants/*adverse effects
MH  - B-Lymphocyte Subsets
MH  - DNA, Viral/blood
MH  - Drug Eruptions/etiology/immunology/virology
MH  - Drug Hypersensitivity/*etiology/immunology/*virology
MH  - Female
MH  - Herpesvirus 6, Human/isolation & purification/*physiology
MH  - Humans
MH  - IgG Deficiency/complications
MH  - Immunoglobulins/blood
MH  - Male
MH  - Middle Aged
MH  - Syndrome
MH  - *Virus Activation
EDAT- 2004/02/18 05:00
MHDA- 2004/03/10 05:00
CRDT- 2004/02/18 05:00
PHST- 2004/02/18 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2004/02/18 05:00 [entrez]
AID - 140/2/183 [pii]
AID - 10.1001/archderm.140.2.183 [doi]
PST - ppublish
SO  - Arch Dermatol. 2004 Feb;140(2):183-8. doi: 10.1001/archderm.140.2.183.