PMID- 14969798
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20071114
IS  - 1078-1439 (Print)
IS  - 1078-1439 (Linking)
VI  - 22
IP  - 1
DP  - 2004 Jan-Feb
TI  - The UroVysion fluorescence in situ hybridization assay is an effective tool for 
      monitoring recurrence of bladder cancer.
PG  - 16-9
AB  - The newly developed UroVysion fluorescence in situ hybridization (FISH) probe was 
      applied to urine specimens from 19 patients being monitored for recurrence of 
      bladder cancer. The results for the multi-target DNA FISH assay were compared 
      with independent analyses of urine cytology and flexible cystoscopy. Patients 
      with tumors identified through the cystoscopy exam were biopsied and/or underwent 
      surgery. In 12 patients with normal cytoscopy, cytology and FISH were also 
      normal. Therefore, the specificity of these two tests was 100%. In 7 patients, a 
      tumor was diagnosed by cystoscopy, and 3 of them had abnormal urine cytology 
      while 6 of them had an abnormal result in the FISH assay. Accordingly, the 
      sensitivity was 43% for the cytology and 87% for the FISH test. Interestingly, a 
      pT1G3 tumor in a bladder diverticulum was not detected by cytology or the FISH 
      test. These results agreed with a large series previously published using similar 
      FISH probes and support the proposal for a multicenter trial to confirm the 
      usefulness of the UroVysion probe as a screening tool to select patients for 
      cystoscopy.
FAU - Varella-Garcia, Marileila
AU  - Varella-Garcia M
AD  - University of Colorado Comprehensive Cancer Center, UCHSC, Denver CO, USA.
FAU - Akduman, Bulent
AU  - Akduman B
FAU - Sunpaweravong, Patrapim
AU  - Sunpaweravong P
FAU - Di Maria, Michael V
AU  - Di Maria MV
FAU - Crawford, E David
AU  - Crawford ED
LA  - eng
GR  - P30-CA46934/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cystoscopy
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*diagnosis
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Urinalysis
MH  - Urinary Bladder Neoplasms/*diagnosis
EDAT- 2004/02/19 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/02/19 05:00
PHST- 2003/01/28 00:00 [received]
PHST- 2003/05/28 00:00 [revised]
PHST- 2003/05/30 00:00 [accepted]
PHST- 2004/02/19 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/02/19 05:00 [entrez]
AID - S107814390300098X [pii]
AID - 10.1016/S1078-1439(03)00098-X [doi]
PST - ppublish
SO  - Urol Oncol. 2004 Jan-Feb;22(1):16-9. doi: 10.1016/S1078-1439(03)00098-X.