PMID- 14969851
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20061115
IS  - 1499-3872 (Print)
VI  - 3
IP  - 1
DP  - 2004 Feb
TI  - Aberration of X chromosome in liver neoplasm detected by fluorescence in situ 
      hybridization.
PG  - 110-4
AB  - BACKGROUND: A diverse range of cytogenetic alterations of autosomal chromosomes 
      has been reported to date. However, few studies have addressed the abnormalities 
      of X chromosome in hepatocellular carcinoma (HCC) except sporadic reports on the 
      deletion of band F1 in X chromosome, and the clonal analysis of methylation 
      pattern of the X chromosome-linked human androgen receptor gene. Identification 
      of specific X chromosome alterations during the course of neoplastic development 
      would be essential to defining the genetic basis of HCC. Therefore, we studied 
      the regularity of aberration of X chromosome in liver cancer. METHODS: 
      Hepatocarcinoma cellular lines and tumor tissues were detected respectively 
      through DNA probes of X chromosome after fluorescence in situ hybridization 
      (FISH). RESULTS: Increased copies of X chromosome were observed in all samples, 
      and four signals of hybridization were of the major type. CONCLUSIONS: Increased 
      copy number of X chromosome frequently occur in liver cancer. The relationship 
      between copy number of X chromosome and liver cancer genesis needs further 
      investigation. This study is the first of its kind determining the copy number of 
      X chromosome in liver cancer by using FISH.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, 
      China. dr_liujun@hotmail.com
FAU - Wang, Zhan-Min
AU  - Wang ZM
FAU - Zhen, Shu-Fang
AU  - Zhen SF
FAU - Wu, Xiao-Peng
AU  - Wu XP
FAU - Ma, Dao-Xin
AU  - Ma DX
FAU - Li, Zhao-Hui
AU  - Li ZH
FAU - Liu, Bo
AU  - Liu B
FAU - Zhao, Zhi-Lun
AU  - Zhao ZL
FAU - Ke, Yang
AU  - Ke Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
SB  - IM
MH  - Adult
MH  - Carcinoma, Hepatocellular/*genetics/surgery
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, X
MH  - Cohort Studies
MH  - Culture Techniques
MH  - Female
MH  - Hepatectomy
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/*genetics/surgery
MH  - Male
MH  - Middle Aged
MH  - Sensitivity and Specificity
EDAT- 2004/02/19 05:00
MHDA- 2004/06/16 05:00
CRDT- 2004/02/19 05:00
PHST- 2004/02/19 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/02/19 05:00 [entrez]
AID - 191 [pii]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2004 Feb;3(1):110-4.