PMID- 14970024
OWN - NLM
STAT- MEDLINE
DCOM- 20040329
LR  - 20210526
IS  - 0195-6108 (Print)
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 25
IP  - 2
DP  - 2004 Feb
TI  - Correlation of angiographic circulation time and cerebrovascular reserve by 
      acetazolamide-challenged single photon emission CT.
PG  - 242-7
AB  - BACKGROUND AND PURPOSE: Although cerebral circulation time (CCT) is one of the 
      main parameters in cerebral blood flow measurements, its clinical significance is 
      controversial. To assess the importance of CCT by using a nondiffusible 
      indicator, we studied the relationship between angiographic CCT and 
      cerebrovascular reserve. METHODS: Twenty-eight patients, each with a unilateral 
      occlusive lesion in the internal carotid artery or middle cerebral artery, were 
      examined. To assess the CCT, the regional arteriocapillary circulation time 
      (rACCT) was measured by angiography and the ratio of the value on the occlusive 
      side to the value on the contralateral side was calculated as the rACCT ratio. To 
      estimate the cerebrovascular reserve, acetazolamide-challenged single photon 
      emission CT was used. Patients with a decreased cerebrovascular reserve were 
      defined as the "poor reserve" group, and those without a decrease were defined as 
      the "normal reserve" group. The ratio of the radioactivity count on the occlusive 
      side to the count on the contralateral side was calculated as the asymmetry 
      index, and the proportion of the acetazolamide-challenged asymmetry index to the 
      baseline asymmetry index was defined as the regional reactivity index. RESULTS: 
      The rACCT ratio in the poor reserve group (n = 19) was significantly (P <.001) 
      larger than that in the normal reserve group (n = 9), and a significant 
      correlation (r = -0.83, P <.01) was found between the rACCT ratio and the 
      regional reactivity index. CONCLUSION: The angiographic CCT and the cerebral 
      vasoreactivity to acetazolamide on single photon emission CT were well 
      correlated, suggesting that measurement of the CCT by using a nondiffusible 
      indicator could be used as an index of cerebrovascular reserve.
FAU - Yamamoto, Shiro
AU  - Yamamoto S
AD  - Department of Neurology, Kansai Rosai Hospital, Hyogo, Japan.
FAU - Watanabe, Manabu
AU  - Watanabe M
FAU - Uematsu, Toshihiko
AU  - Uematsu T
FAU - Takasawa, Kenichiro
AU  - Takasawa K
FAU - Nukata, Masaru
AU  - Nukata M
FAU - Kinoshita, Naokazu
AU  - Kinoshita N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - O3FX965V0I (Acetazolamide)
SB  - IM
MH  - *Acetazolamide
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Flow Velocity/drug effects/physiology
MH  - *Carbonic Anhydrase Inhibitors
MH  - *Carotid Artery, Internal/drug effects/physiopathology
MH  - Carotid Stenosis/*diagnosis/physiopathology
MH  - *Cerebral Angiography
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Infarction, Middle Cerebral Artery/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Regional Blood Flow/drug effects/physiology
MH  - Retrospective Studies
MH  - *Tomography, Emission-Computed, Single-Photon
MH  - Vascular Resistance/drug effects/physiology
PMC - PMC7974592
EDAT- 2004/02/19 05:00
MHDA- 2004/03/30 05:00
PMCR- 2005/02/01
CRDT- 2004/02/19 05:00
PHST- 2004/02/19 05:00 [pubmed]
PHST- 2004/03/30 05:00 [medline]
PHST- 2004/02/19 05:00 [entrez]
PHST- 2005/02/01 00:00 [pmc-release]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2004 Feb;25(2):242-7.