PMID- 14975167
OWN - NLM
STAT- MEDLINE
DCOM- 20040429
LR  - 20181113
IS  - 1471-2156 (Electronic)
IS  - 1471-2156 (Linking)
VI  - 4 Suppl 1
IP  - Suppl 1
DP  - 2003 Dec 31
TI  - Structural equation model-based genome scan for the metabolic syndrome.
PG  - S99
AB  - BACKGROUND: The metabolic syndrome is characterized by the clustering of several 
      traits, including obesity, hypertension, decreased levels of HDL cholesterol, and 
      increased levels of glucose and triglycerides. Because these traits cluster, 
      there are likely common genetic factors involved. RESULTS: We used a multivariate 
      structural equation model (SEM) approach to scan the genome for loci involved in 
      the metabolic syndrome. We found moderate evidence for linkage on chromosomes 2, 
      3, 11, 13, and 15, and these loci appear to have different relative effects on 
      the component traits of the metabolic syndrome. CONCLUSION: Our results suggest 
      that the metabolic syndrome components, diabetes, obesity, and hypertension, are 
      under the pleiotropic control of several loci.
FAU - Stein, Catherine M
AU  - Stein CM
AD  - Department of Epidemiology and Biostatistics, Case Western Reserve University 
      2500 MetroHealth Dr, R258 Rammelkamp Building, Cleveland, Ohio, USA. 
      kasia@darwin.cwru.edu
FAU - Song, Yeunjoo
AU  - Song Y
FAU - Elston, Robert C
AU  - Elston RC
FAU - Jun, Gyungah
AU  - Jun G
FAU - Tiwari, Hemant K
AU  - Tiwari HK
FAU - Iyengar, Sudha K
AU  - Iyengar SK
LA  - eng
GR  - R37 GM028356/GM/NIGMS NIH HHS/United States
GR  - P41 RR003655/RR/NCRR NIH HHS/United States
GR  - RR08123/RR/NCRR NIH HHS/United States
GR  - R01 HG001577/HG/NHGRI NIH HHS/United States
GR  - 1 P41 RR 03655/RR/NCRR NIH HHS/United States
GR  - RR03655/RR/NCRR NIH HHS/United States
GR  - HL07567/HL/NHLBI NIH HHS/United States
GR  - HG01577/HG/NHGRI NIH HHS/United States
GR  - GM28356/GM/NIGMS NIH HHS/United States
GR  - DK57292/DK/NIDDK NIH HHS/United States
GR  - R29 HG001577/HG/NHGRI NIH HHS/United States
GR  - T32 HL007567/HL/NHLBI NIH HHS/United States
GR  - U01 DK057292/DK/NIDDK NIH HHS/United States
GR  - DK54644/DK/NIDDK NIH HHS/United States
GR  - MH01458/MH/NIMH NIH HHS/United States
GR  - R01 GM028356/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20031231
PL  - England
TA  - BMC Genet
JT  - BMC genetics
JID - 100966978
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Genes/physiology
MH  - Genetic Markers/genetics
MH  - Genetic Testing/*statistics & numerical data
MH  - *Genome, Human
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*epidemiology/*genetics
MH  - Middle Aged
MH  - *Models, Genetic
MH  - Multivariate Analysis
MH  - Quantitative Trait Loci/genetics
MH  - Quantitative Trait, Heritable
PMC - PMC1866540
EDAT- 2004/02/21 05:00
MHDA- 2004/04/30 05:00
PMCR- 2003/12/31
CRDT- 2004/02/21 05:00
PHST- 2004/02/21 05:00 [pubmed]
PHST- 2004/04/30 05:00 [medline]
PHST- 2004/02/21 05:00 [entrez]
PHST- 2003/12/31 00:00 [pmc-release]
AID - 1471-2156-4-S1-S99 [pii]
AID - 10.1186/1471-2156-4-S1-S99 [doi]
PST - epublish
SO  - BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S99. doi: 10.1186/1471-2156-4-S1-S99.