PMID- 14975686
OWN - NLM
STAT- MEDLINE
DCOM- 20040421
LR  - 20141120
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 46
IP  - 3
DP  - 2004 Mar
TI  - An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors 
      and p42/44 MAP kinase in the dentate gyrus in vitro.
PG  - 311-7
AB  - The induction of long-term potentiation (LTP) under conditions of blockade of the 
      N-methyl-D-aspartate receptor (NMDAR) was studied in the medial perforant path to 
      granule cell synapse in the dentate gyrus. A small amplitude NMDAR-independent 
      potentiation was induced by a single brief high frequency stimulation (HFS), and 
      a summated larger LTP was induced by repeated spaced HFS. The NMDAR-independent 
      LTP was mediated by activation of group II mGluR as it was inhibited by the group 
      II antagonists EGLU and also low concentrations of LY341495, but not the group I 
      mGluR antagonist MPEP. Perfusion of the group II mGluR agonist DCG-IV induced 
      NMDAR-independent LTP in media containing an NMDAR antagonist. The 
      NMDAR-independent LTP induced by HFS was mediated via activation of p42/44 MAP 
      kinase as it was blocked by the selective inhibitor PD98059.
FAU - Wu, JianQun
AU  - Wu J
AD  - Department of Physiology, Trinity College, Dublin 2, Ireland.
FAU - Rowan, Michael J
AU  - Rowan MJ
FAU - Anwyl, Roger
AU  - Anwyl R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amino Acids)
RN  - 0 (Cyclopropanes)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (LY 341495)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Xanthenes)
RN  - 0 (metabotropic glutamate receptor 2)
RN  - 147782-19-2 (2-(2,3-dicarboxycyclopropyl)glycine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Amino Acids/pharmacology
MH  - Animals
MH  - Cyclopropanes/pharmacology
MH  - Dentate Gyrus/drug effects/*physiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Glycine/*analogs & derivatives/pharmacology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/*physiology
MH  - Mitogen-Activated Protein Kinase 3
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
MH  - Receptors, N-Methyl-D-Aspartate/agonists/antagonists & inhibitors/physiology
MH  - Xanthenes/pharmacology
EDAT- 2004/02/21 05:00
MHDA- 2004/04/22 05:00
CRDT- 2004/02/21 05:00
PHST- 2003/04/11 00:00 [received]
PHST- 2003/09/10 00:00 [revised]
PHST- 2003/09/24 00:00 [accepted]
PHST- 2004/02/21 05:00 [pubmed]
PHST- 2004/04/22 05:00 [medline]
PHST- 2004/02/21 05:00 [entrez]
AID - S0028390803003800 [pii]
AID - 10.1016/j.neuropharm.2003.09.014 [doi]
PST - ppublish
SO  - Neuropharmacology. 2004 Mar;46(3):311-7. doi: 10.1016/j.neuropharm.2003.09.014.