PMID- 14975803 OWN - NLM STAT- MEDLINE DCOM- 20040308 LR - 20091111 IS - 0007-4551 (Print) IS - 0007-4551 (Linking) VI - 91 IP - 1 DP - 2004 Jan TI - [Cytogenetics, cytogenomics and cancer: 2004 update]. PG - 29-43 AB - Cytogenetics has clearly established the key role chromosomal rearrangements play in neoplastic initiation and progression. Investigation methods have evolved considerably from banding analysis of chromosome morphology to fluorescence in situ hybridization (FISH) and now to comparative genomic hybridization (CGH) on chromosomes or micro-array analysis of DNA. In addition to its contributions to the description, prognosis and understanding of oncogenesis and tumor progression, cytogenomics provides the information required for the rational use of new targeted therapies among which Imatimib is the most achieved example. CI - Copyright John Libbey Eurotext 2003. FAU - Bernheim, Alain AU - Bernheim A AD - UMR 8125 CNRS, Institut Gustave-Roussy, Villejuif, France. bernheim@igr.fr FAU - Huret, Jean-Louis AU - Huret JL FAU - Guillaud-Bataille, Marine AU - Guillaud-Bataille M FAU - Brison, Olivier AU - Brison O FAU - Couturiers, Jerome AU - Couturiers J CN - Groupe Francais de Cytogenetique Oncologique LA - fre PT - English Abstract PT - Journal Article PT - Review TT - De la cytogenetique a la cytogenomique des tumeurs : le point en 2004. PL - France TA - Bull Cancer JT - Bulletin du cancer JID - 0072416 SB - IM MH - *Chromosome Aberrations MH - Cytogenetic Analysis MH - Databases, Genetic MH - Genome, Human MH - Genomics/methods/*trends MH - Humans MH - In Situ Hybridization, Fluorescence MH - Neoplasms/diagnosis/*genetics/therapy MH - Nucleic Acid Hybridization/methods MH - Oligonucleotide Array Sequence Analysis RF - 33 EDAT- 2004/02/21 05:00 MHDA- 2004/03/09 05:00 CRDT- 2004/02/21 05:00 PHST- 2004/02/21 05:00 [pubmed] PHST- 2004/03/09 05:00 [medline] PHST- 2004/02/21 05:00 [entrez] PST - ppublish SO - Bull Cancer. 2004 Jan;91(1):29-43.