PMID- 14976596
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 5
DP  - 2004 Mar 1
TI  - Human leukocyte antigen class I supertypes influence susceptibility and severity 
      of tuberculosis.
PG  - 805-11
AB  - Although both differential susceptibility to Mycobacterium tuberculosis infection 
      and disease pathogenesis depend on a multitude of factors, elucidation of 
      specific host genetic markers, particularly those in the human major 
      histocompatibility complex, is important. The present study is an attempt to 
      delineate human leukocyte antigen (HLA) class I association in tuberculosis (TB) 
      on the basis of a shared sequence motif in peptide-binding pockets of HLA 
      molecules. In patients with pulmonary TB and miliary/disseminated TB, we observed 
      significantly increased frequencies of A3-like supertypes and decreased 
      frequencies of A1-like supertypes. These 2 positively and negatively associated 
      supertypes (allele groups) share a similar peptide-binding motif, except for 
      residues in pocket F of the HLA class I molecules. In addition, the HLA-Cw 
      specificities that are major ligands for killer cell immunoglobulin-like 
      (inhibitory) receptors (KIRs), particularly KIR2DL1 (Cw2, Cw4, and CW5) and 
      KIR2DL2 (Cw1, Cw3, and Cw7), were found more frequently among patients with TB, 
      which suggests a possible inhibition of natural killer cell activity against the 
      infected target cells. The results of the present study suggest that the frequent 
      occurrence of HLA class I specificities comprising an A3-like peptide-binding 
      motif and the increased occurrence of ligands for KIR2DL in TB together may 
      influence the outcome of TB.
FAU - Balamurugan, Arumugam
AU  - Balamurugan A
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Sharma, Surendra K
AU  - Sharma SK
FAU - Mehra, Narinder K
AU  - Mehra NK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040216
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Cohort Studies
MH  - Disease Susceptibility/*immunology
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Mycobacterium tuberculosis/immunology/*pathogenicity
MH  - Reference Values
MH  - Tuberculosis, Multidrug-Resistant/genetics/immunology
MH  - Tuberculosis, Pulmonary/*immunology
EDAT- 2004/02/21 05:00
MHDA- 2004/04/24 05:00
CRDT- 2004/02/21 05:00
PHST- 2003/07/04 00:00 [received]
PHST- 2003/08/28 00:00 [accepted]
PHST- 2004/02/21 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2004/02/21 05:00 [entrez]
AID - JID31401 [pii]
AID - 10.1086/381689 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Mar 1;189(5):805-11. doi: 10.1086/381689. Epub 2004 Feb 16.