PMID- 14976605
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20181130
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 5
DP  - 2004 Mar 1
TI  - Polymorphism of transporter associated with antigen presentation 1 as a potential 
      determinant for severity of disease in recurrent respiratory papillomatosis 
      caused by human papillomavirus types 6 and 11.
PG  - 871-9
AB  - Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human 
      papillomaviruses (HPVs). It is characterized by multiple recurrences of benign 
      neoplasms and has a variable clinical course, ranging from infrequent recurrence 
      to acute airway obstruction. One way in which HPV subverts the immune system in 
      RRP is by interfering with TAP1 (transporter associated with antigen presentation 
      1). We examined whether a known TAP1 polymorphism in the ATPase domain altered 
      the severity of disease in patients with RRP. The presence of this polymorphism 
      was significantly correlated with severity of disease (P=.015). Because of the 
      proximity of the TAP1 gene to human leukocyte antigen (HLA) class II genes on 
      chromosome 6, we postulated that a linkage disequilibrium may exist. Of the 
      patients with polymorphic TAP1, 36% were positive for HLA-DRB1*0102 (P=.021; 
      P=.147 with Bonferroni's correction). However, this association appeared to 
      mitigate the severity of disease (P=.04). Therefore, severity of disease in a 
      patient with RRP might be determined by sequencing TAP1, in conjunction with HLA 
      class II genes.
FAU - Vambutas, Andrea
AU  - Vambutas A
AD  - North Shore-Long Island Jewish Research Institute, and Department of 
      Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, 
      USA. vambutas@lij.edu.
FAU - Bonagura, Vincent R
AU  - Bonagura VR
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Abramson, Allan L
AU  - Abramson AL
FAU - Mullooly, Virginia
AU  - Mullooly V
FAU - DeVoti, James
AU  - DeVoti J
FAU - Gjertson, David W
AU  - Gjertson DW
FAU - Steinberg, Bettie M
AU  - Steinberg BM
LA  - eng
GR  - P50 DC000203/DC/NIDCD NIH HHS/United States
GR  - K23 DC00155/DC/NIDCD NIH HHS/United States
GR  - P50 DC00203/DC/NIDCD NIH HHS/United States
GR  - R03 DC05150/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040216
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (TAP1 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/*genetics/immunology
MH  - Chromosomes, Human, Pair 6/genetics
MH  - HLA-D Antigens/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Major Histocompatibility Complex
MH  - *Papillomaviridae
MH  - Papillomavirus Infections/*genetics/immunology/physiopathology
MH  - *Polymorphism, Genetic
MH  - Recurrence
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2004/02/21 05:00
MHDA- 2004/04/24 05:00
CRDT- 2004/02/21 05:00
PHST- 2003/03/24 00:00 [received]
PHST- 2003/09/07 00:00 [accepted]
PHST- 2004/02/21 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2004/02/21 05:00 [entrez]
AID - JID30862 [pii]
AID - 10.1086/381764 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Mar 1;189(5):871-9. doi: 10.1086/381764. Epub 2004 Feb 16.