PMID- 14979405
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20191108
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 10
IP  - 1
DP  - 2004 Jan
TI  - Laboratory diagnosis of heparin-induced thrombocytopenia in Asian Indians as 
      investigated with functional and immunologic methods.
PG  - 51-4
AB  - Heparin-induced thrombocytopenia (HIT) was looked for in 33 Indian patients 
      undergoing cardiovascular surgery who received unfractionated heparin (UFH). 
      Platelet counts were performed before the initiation of UFH therapy and 5 to 16 
      days after administration of the therapy. A decrease in patients' platelet count 
      > 35% of the baseline value or < 100,000/microL was considered to be suggestive 
      of HIT syndrome. Heparin-induced platelet aggregation (HIPA) and enzyme-linked 
      immunosorbent assay (ELISA) tests were performed in all the patients to detect 
      antibodies against heparin/PF4 complex. Thrombocytopenia was found to be present 
      in 10 (30%) patients. Of these, two patients were found to be positive as 
      detected by HIPA and ELISA tests. These two patients were considered to have 
      classic HIT syndrome. One of these had bleeding while the other was asymptomatic. 
      Among the 23 non-thrombocytopenic patients and controls, HIT antibodies were not 
      detectable by HIPA test in all but absent by ELISA in only 21 of them. Two of 23 
      non-thrombocytopenic patients had positive results on the ELISA test. Because the 
      latter had negative test results on HIPA, they were considered to be 
      false-positive results. Thus, HIT syndrome develops in approximately 6% of Indian 
      patients treated with UFH.
FAU - Kannan, Meganathan
AU  - Kannan M
AD  - Department of Haematology, All India Institute of Medical Sciences, Ansari Nagar, 
      New Delhi, India.
FAU - Ahmed, Rafeeq
AU  - Ahmed R
FAU - Kale, Shailaja
AU  - Kale S
FAU - Ahmad, Sarfraz
AU  - Ahmad S
FAU - Fareed, Jawed
AU  - Fareed J
FAU - Saxena, Renu
AU  - Saxena R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Cardiac Surgical Procedures
MH  - Clinical Laboratory Techniques
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Heparin/*adverse effects
MH  - Humans
MH  - India/epidemiology
MH  - Platelet Aggregation/drug effects
MH  - Platelet Count
MH  - Platelet Function Tests
MH  - Prevalence
MH  - Thrombocytopenia/*chemically induced/diagnosis/*epidemiology
EDAT- 2004/02/26 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - 10.1177/107602960401000108 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2004 Jan;10(1):51-4. doi: 10.1177/107602960401000108.