PMID- 1497964
OWN - NLM
STAT- MEDLINE
DCOM- 19920917
LR  - 20190907
IS  - 1034-4810 (Print)
IS  - 1034-4810 (Linking)
VI  - 28
IP  - 4
DP  - 1992 Aug
TI  - Failure of allogeneic bone marrow transplantation to benefit HIV infection.
PG  - 331-3
AB  - A 16 year old boy underwent allogeneic bone marrow transplantation (BMT) from an 
      human leukocyte antigen (HLA)-identical sibling for severe aplastic anaemia. He 
      was symptomatic for 7 years before transplantation and had received multiple red 
      blood cell and platelet transfusions. Conditioning for BMT consisted of 
      cyclophosphamide, antilymphocyte globulin and total lymphoid irradiation. 
      Engraftment was rapid, there was no evidence of rejection despite the history of 
      multiple blood product transfusions and he did not develop acute or chronic graft 
      versus host disease. He was well for the first 8 months after transplantation but 
      then developed fevers, interstitial pneumonia, herpes simplex infections and 
      cytomegalovirus enteritis. Serological studies revealed antibodies to human 
      immunodeficiency virus (HIV) and he was considered to have acquired immune 
      deficiency syndrome (AIDS). Retrospective analysis of the serum samples showed 
      that he was seronegative for HIV until approximately 10 months before 
      transplantation when his serum became HIV positive. Lymphocyte function studies 
      done after transplantation suggested immunologic recovery at 3 months 
      post-transplant with a brisk though subnormal response to phytohaemagglutinin 
      stimulation. T cell subset analysis performed subsequently showed complete 
      absence of CD4 positive cells indicating immune incompetence which was associated 
      with clinical features of AIDS. Bone marrow transplantation had failed to produce 
      sustained immunologic reconstitution and prevent the progression of HIV to which 
      he ultimately succumbed.
FAU - Giri, N
AU  - Giri N
AD  - Department of Paediatric Haematology and Oncology, Prince of Wales Children's 
      Hospital, Randwick, New South Wales, Australia.
FAU - Vowels, M R
AU  - Vowels MR
FAU - Ziegler, J B
AU  - Ziegler JB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*etiology/immunology
MH  - Adult
MH  - Anemia, Aplastic/*therapy
MH  - Blood Component Transfusion/*adverse effects
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - *HIV-1
MH  - Humans
MH  - Male
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1111/j.1440-1754.1992.tb02681.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 1992 Aug;28(4):331-3. doi: 
      10.1111/j.1440-1754.1992.tb02681.x.