PMID- 14980616
OWN - NLM
STAT- MEDLINE
DCOM- 20041015
LR  - 20220321
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 12
IP  - 5
DP  - 2004 Mar 1
TI  - Synthesis and evaluation of substituted 4-aryloxy- and 
      4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell 
      proliferation.
PG  - 1029-36
AB  - Several substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles were 
      synthesized and evaluated for cytotoxic activity against estrogen-positive, 
      estrogen-negative, and adriamycin-resistant human breast cancer cell lines. 
      4-[4'-(3,4-Dichlorophenoxy)-phenyl]-thiazol-2-yl ammonium iodide demonstrated 
      potent activity against both estrogen-positive and negative breast cancer cell 
      lines with low micromolar (microM) GI(50) values. In addition, we have identified 
      several 2-aminothiazoles that demonstrated selective potency for the 
      adriamycin-resistant and estrogen-negative breast cancer cell lines. The results 
      suggest that these 2-aminothiazoles represent lead compounds for evaluation in 
      animal models of breast cancer.
FAU - Gorczynski, Michael J
AU  - Gorczynski MJ
AD  - Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
FAU - Leal, Rachel M
AU  - Leal RM
FAU - Mooberry, Susan L
AU  - Mooberry SL
FAU - Bushweller, John H
AU  - Bushweller JH
FAU - Brown, Milton L
AU  - Brown ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Estrogens)
RN  - 0 (Thiazoles)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Breast Neoplasms/*pathology
MH  - Cell Division/drug effects
MH  - Cell Line, Tumor
MH  - Doxorubicin
MH  - Drug Resistance, Neoplasm
MH  - Estrogens/analysis
MH  - Female
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Structure-Activity Relationship
MH  - Thiazoles/*chemical synthesis/*pharmacology
EDAT- 2004/02/26 05:00
MHDA- 2004/10/16 09:00
CRDT- 2004/02/26 05:00
PHST- 2003/08/22 00:00 [received]
PHST- 2003/11/25 00:00 [revised]
PHST- 2003/12/10 00:00 [accepted]
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/10/16 09:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - S0968089603008514 [pii]
AID - 10.1016/j.bmc.2003.12.003 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2004 Mar 1;12(5):1029-36. doi: 10.1016/j.bmc.2003.12.003.