PMID- 14981192
OWN - NLM
STAT- MEDLINE
DCOM- 20050121
LR  - 20190514
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 62
IP  - 4
DP  - 2004 Feb 24
TI  - Heparin-induced thrombocytopenia in neurologic disease treated with 
      unfractionated heparin.
PG  - 657-9
AB  - The risk for immune-mediated heparin-induced thrombocytopenia (HIT) in neurologic 
      patients receiving unfractionated heparin (UFH) is not known. In a prospective 
      study of 200 patients, the authors found a 2.5% rate of HIT and a 2% rate of 
      HIT-associated thromboses, suggesting that neurologic patients treated with UFH 
      are at considerable risk for development of HIT and its complications. Prevalence 
      of heparin-induced antibodies was 20.5% and was dependent on heparin dose. It was 
      higher in cerebrovascular than in noncerebrovascular (29.4% versus 11.2%, p < 
      0.01) patients.
FAU - Harbrecht, U
AU  - Harbrecht U
AD  - Institute for Experimental Haematology and Transfusion Medicine, Rheinische 
      Friedrich Wilhelms Universitat, Bonn, Germany. ursula.harbrecht@ukb.uni-bonn.de
FAU - Bastians, B
AU  - Bastians B
FAU - Kredteck, A
AU  - Kredteck A
FAU - Hanfland, P
AU  - Hanfland P
FAU - Klockgether, T
AU  - Klockgether T
FAU - Pohl, C
AU  - Pohl C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cerebrovascular Disorders/blood/complications/drug therapy/immunology
MH  - Female
MH  - Heparin/*adverse effects/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/blood/complications/*drug therapy/immunology
MH  - Prevalence
MH  - Prospective Studies
MH  - Purpura, Thrombocytopenic, Idiopathic/*chemically induced/epidemiology/immunology
MH  - Risk
MH  - Thrombosis/epidemiology/etiology
EDAT- 2004/02/26 05:00
MHDA- 2005/01/22 09:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2005/01/22 09:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - 10.1212/01.wnl.0000110187.16764.9a [doi]
PST - ppublish
SO  - Neurology. 2004 Feb 24;62(4):657-9. doi: 10.1212/01.wnl.0000110187.16764.9a.