PMID- 14981440
OWN - NLM
STAT- MEDLINE
DCOM- 20040330
LR  - 20161124
IS  - 0741-5214 (Print)
IS  - 0741-5214 (Linking)
VI  - 39
IP  - 3
DP  - 2004 Mar
TI  - Dietary folate and vitamin B6 are independent predictors of peripheral arterial 
      occlusive disease.
PG  - 513-6
AB  - BACKGROUND: It has been suggested that hyperhomocysteinemia (HHcy) is an 
      independent risk factor for peripheral arterial occlusive disease (PAOD). 
      However, the relationship between dietary folate and vitamin B6, cofactors in the 
      metabolism of homocysteine (Hcy), and PAOD is unclear. AIMS: To study the 
      relationship between dietary folate and B6 and PAOD. METHODS: Case-control 
      population based study of 392 men older than 50 years living in Huntingdon, 
      United Kingdom. PAOD, defined as an ankle-brachial pressure index (ABPI) < 0.9, 
      was present in 86 (22%) of subjects. Folate, vitamin B6, and vitamin B12 intakes 
      were calculated by means of the EPIC (European Prospective Investigation into 
      Cancer) food frequency questionnaire. RESULTS: Daily folate intake was 
      significantly lower in case subjects (mean, 288; 95% confidence interval [CI], 
      266-309 microg) than in control subjects (324; 95% CI, 313-335 microg). Daily 
      vitamin B6 intake was also lower in case subjects (2.05; 95% CI, 1.92-2.19 mg 
      versus 2.26; 95% CI, 2.19-2.33 mg). Daily folate and vitamin B6 intakes were 
      independent predictors of PAOD after adjusting for age, blood pressure, 
      cholesterol levels, diabetes, and smoking status in a logistic regression model. 
      This model suggests that increasing daily folate intake by 1 standard deviation 
      decreased the risk of PAOD by 46%. A similar increase in daily vitamin B6 intake 
      decreased the risk of PAOD by 29%. CONCLUSION: In men older than 50 years, 
      dietary folate and B6 intakes are independent predictors of PAOD. Longitudinal 
      studies are required to determine whether dietary modification can reduce the 
      incidence of PAOD in the population.
FAU - Wilmink, Antonius B M
AU  - Wilmink AB
AD  - University Department of Vascular Surgery, Birmingham Heartlands Hospital, 
      University of Birmingham, Birmingham, UK. abmw100@doctors.org.uk
FAU - Welch, Ailsa A
AU  - Welch AA
FAU - Quick, Clive R G
AU  - Quick CR
FAU - Burns, Paul J
AU  - Burns PJ
FAU - Hubbard, C S
AU  - Hubbard CS
FAU - Bradbury, Andrew W
AU  - Bradbury AW
FAU - Day, Nicholas E
AU  - Day NE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
RN  - 8059-24-3 (Vitamin B 6)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arterial Occlusive Diseases/epidemiology/*prevention & control
MH  - Cohort Studies
MH  - Diet/*statistics & numerical data
MH  - Diet Surveys
MH  - *Folic Acid
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/epidemiology/*prevention & control
MH  - Risk Factors
MH  - United Kingdom/epidemiology
MH  - Vitamin B 12
MH  - *Vitamin B 6
EDAT- 2004/02/26 05:00
MHDA- 2004/03/31 05:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/03/31 05:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - S0741521403015672 [pii]
AID - 10.1016/j.jvs.2003.09.046 [doi]
PST - ppublish
SO  - J Vasc Surg. 2004 Mar;39(3):513-6. doi: 10.1016/j.jvs.2003.09.046.