PMID- 14981598
OWN - NLM
STAT- MEDLINE
DCOM- 20040513
LR  - 20220410
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 43
IP  - 3
DP  - 2004 Mar
TI  - Urinary interleukin-18 is a marker of human acute tubular necrosis.
PG  - 405-14
AB  - BACKGROUND: Interleukin-18 (IL-18) is a mediator of ischemic acute tubular 
      necrosis (ATN) in mice. METHODS: IL-18 was measured in human urine to determine 
      whether it might serve as a marker of ATN. Seventy-two patients, including 
      healthy controls, patients with different forms of acute renal failure, and 
      patients with other renal diseases, were studied. RESULTS: Patients with ATN had 
      significantly greater median urinary IL-18 concentrations than those with all 
      other conditions: patients with ATN, 644 pg/mg creatinine (mean, 814 +/- 151 [SE] 
      pg/mg creatinine; P <0.0001) versus healthy controls, 16 pg/mg creatinine (mean, 
      23 +/- 9 pg/mg creatinine); patients with prerenal azotemia, 63 pg/mg creatinine 
      (mean, 155 +/- 68 pg/mg creatinine); patients with urinary tract infection, 63 
      pg/mg creatinine (mean, 149 +/- 110 pg/mg creatinine); those with chronic renal 
      insufficiency, 12 pg/mg creatinine (mean, 84 +/- 45 pg/mg creatinine); and 
      patients with nephrotic syndrome, 34 pg/mg creatinine (mean, 67 +/- 47 pg/mg 
      creatinine). Median urinary IL-18 concentrations measured in the first 24 hours 
      after kidney transplantation were 924 pg/mg creatinine (mean, 1,199 +/- 187 pg/mg 
      creatinine) in patients who received a cadaveric kidney that developed delayed 
      graft function compared with 171 pg/mg creatinine (mean, 367 +/- 102 pg/mg 
      creatinine) in patients who received a cadaveric kidney with prompt graft 
      function and 73 pg/mg creatinine (mean, 176 +/- 107 pg/mg creatinine) in patients 
      who received a kidney with prompt graft function from a living donor (P <0.002). 
      In kidney transplant recipients, lower urinary IL-18 levels were associated with 
      a steeper decline in serum creatinine concentrations postoperative days 0 to 4 (P 
      = 0.009). CONCLUSION: IL-18 levels are elevated in urine in patients with ATN and 
      delayed graft function compared with other renal diseases. Urinary IL-18 may 
      serve as a marker for proximal tubular injury in ATN. The clinical application of 
      this test may be substantial because it is reliable, inexpensive, and easy to 
      perform.
FAU - Parikh, Chirag R
AU  - Parikh CR
AD  - Department of Medicine, University of Colorado School of Medicine, Denver, CO 
      80262, USA.
FAU - Jani, Alkesh
AU  - Jani A
FAU - Melnikov, Vyacheslav Y
AU  - Melnikov VY
FAU - Faubel, Sarah
AU  - Faubel S
FAU - Edelstein, Charles L
AU  - Edelstein CL
LA  - eng
GR  - 1R01-DK56851/DK/NIDDK NIH HHS/United States
GR  - K23-DK064689-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-18/*urine
MH  - Kidney Diseases/urine
MH  - Kidney Tubular Necrosis, Acute/*urine
MH  - Male
MH  - Middle Aged
EDAT- 2004/02/26 05:00
MHDA- 2004/05/14 05:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/05/14 05:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - S0272638603014999 [pii]
AID - 10.1053/j.ajkd.2003.10.040 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2004 Mar;43(3):405-14. doi: 10.1053/j.ajkd.2003.10.040.