PMID- 14981771
OWN - NLM
STAT- MEDLINE
DCOM- 20040430
LR  - 20131121
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 72
IP  - 4
DP  - 2004 Apr
TI  - Risk factors and clinical consequences of human herpesvirus 7 infection in 
      paediatric haematopoietic stem cell transplant recipients.
PG  - 668-74
AB  - Human herpesvirus 7 (HHV-7) is the least studied beta-herpesvirus in transplant 
      settings. This prospective study examined the activity of HHV-7 during the first 
      12 weeks post-stem cell transplant in 59 paediatric patients. The presence of 
      HHV-7, human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6) in blood was 
      monitored weekly by a multiplex nested polymerase chain reaction. Overall, 33 
      (55.9%) patients had one or more surveillance blood sample(s) positive for HHV-7. 
      In contrast to HCMV and HHV-6, no obvious peak time of reactivation was observed 
      for HHV-7. The occurrence of HHV-7 DNAaemia showed a significant negative 
      association with HHV-6 (P=0.022), but with no association with HCMV. A 
      significant higher positive rate for HHV-7 was found in autologous versus 
      allogeneic (P=0.002), and in peripheral blood versus umbilical cord/marrow 
      (P<0.001) transplant. Acyclovir had no effect, whereas ganciclovir was associated 
      with a lower rate of HHV-7 reactivation (P=0.009). One patient died of HHV-7 
      associated brain stem encephalitis. The administration of colony stimulating 
      factor, occurrence of acute graft versus host disease, time to neutrophil and 
      platelet engraftment showed no significant association with the occurrence of 
      HHV-7 DNAaemia.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Chan, Paul K S
AU  - Chan PK
AD  - Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales 
      Hospital, Shatin, New Territories, Hong Kong SAR, China. paulkschan@cuhk.edu.hk
FAU - Li, C K
AU  - Li CK
FAU - Chik, K W
AU  - Chik KW
FAU - Lee, Vincent
AU  - Lee V
FAU - Shing, Matthew M K
AU  - Shing MM
FAU - Ng, K C
AU  - Ng KC
FAU - Cheung, Jo L K
AU  - Cheung JL
FAU - Fok, T F
AU  - Fok TF
FAU - Cheng, Augustine F
AU  - Cheng AF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antiviral Agents)
RN  - 0 (Colony-Stimulating Factors)
RN  - 0 (DNA, Viral)
RN  - P9G3CKZ4P5 (Ganciclovir)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/therapeutic use
MH  - Antiviral Agents/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Colony-Stimulating Factors/administration & dosage
MH  - Cord Blood Stem Cell Transplantation
MH  - Cytomegalovirus/isolation & purification
MH  - Cytomegalovirus Infections/virology
MH  - DNA, Viral/blood
MH  - Female
MH  - Ganciclovir/therapeutic use
MH  - Graft vs Host Disease
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Herpesviridae Infections/virology
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Prospective Studies
MH  - Risk Factors
MH  - Roseolovirus Infections/*epidemiology/virology
MH  - Viremia
EDAT- 2004/02/26 05:00
MHDA- 2004/05/01 05:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/05/01 05:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - 10.1002/jmv.20032 [doi]
PST - ppublish
SO  - J Med Virol. 2004 Apr;72(4):668-74. doi: 10.1002/jmv.20032.