PMID- 14982506
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20230120
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 3
DP  - 2004 Mar
TI  - Allergic cross-reactivity: from gene to the clinic.
PG  - 243-67
AB  - A large number of allergenic proteins have now their complete cDNA sequences 
      determined and in some cases also the 3D structures. It turned out that most 
      allergens could be grouped into a small number of structural protein families, 
      regardless of their biological source. Structural similarity among proteins from 
      diverse sources is the molecular basis of allergic cross-reactivity. The clinical 
      relevance of immunoglobulin E (IgE) cross-reactivity seems to be influenced by a 
      number of factors including the immune response against the allergen, exposure 
      and the allergen. As individuals are exposed to a variable number of allergenic 
      sources bearing homologous molecules, the exact nature of the antigenic structure 
      inducing the primary IgE immune response cannot be easily defined. In general, 
      the 'cross-reactivity' term should be limited to defined clinical manifestations 
      showing reactivity to a source without previous exposure. 'Co-recognition', 
      including by definition 'cross-reactivity', could be used to describe the large 
      majority of the IgE reactivity where co-exposure to a number of sources bearing 
      homologous molecules do not allow unequivocal identification of the sensitizing 
      molecule. The analysis of reactivity clusters in diagnosis allows the 
      interpretation of the patient's reactivity profile as a result of the 
      sensitization process, which often begins with exposure to a single allergenic 
      molecule.
FAU - Ferreira, F
AU  - Ferreira F
AD  - Department of Genetics and General Biology, University of Salzburg, Austria.
FAU - Hawranek, T
AU  - Hawranek T
FAU - Gruber, P
AU  - Gruber P
FAU - Wopfner, N
AU  - Wopfner N
FAU - Mari, A
AU  - Mari A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/chemistry/genetics/*immunology
MH  - Animals
MH  - Computational Biology
MH  - Cross Reactions
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Immunoglobulin E/immunology
RF  - 219
EDAT- 2004/02/26 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - ALL407 [pii]
AID - 10.1046/j.1398-9995.2003.00407.x [doi]
PST - ppublish
SO  - Allergy. 2004 Mar;59(3):243-67. doi: 10.1046/j.1398-9995.2003.00407.x.