PMID- 14983406
OWN - NLM
STAT- MEDLINE
DCOM- 20040923
LR  - 20090219
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 36
IP  - 1
DP  - 2004 Jan
TI  - Serum IL-18 levels are not increased in patients with untreated Graves' 
      ophthalmopathy.
PG  - 44-7
AB  - OBJECTIVE: Cytokines play an important role in autoimmune thyroid diseases, and 
      serum levels may reflect the activity of the immune process. This is particularly 
      interesting in Graves' ophthalmopathy, where a reliable serum activity marker is 
      warranted. Interleukin-18 (IL-18) is a potent Th1 cytokine, known to induce 
      interferon (IFN)-gamma and the aim of this study was to evaluate serum IL-18 
      levels in Graves' ophthalmopathy. METHODS: Serum IL-18 was measured by ELISA in 
      52 patients with untreated Graves' ophthalmopathy (who all had been rendered 
      euthyroid with antithyroid drugs), 52 healthy controls matched for sex, age, and 
      smoking habits, and 15 euthyroid patients who had been treated for Graves' 
      hyperthyroidism and ophthalmopathy in the past. RESULTS: Serum IL-18 (median 
      values in pg/ml with range) levels did not differ between the untreated Graves' 
      ophthalmopathy patients-226 (61-704) pg/ml, matched healthy controls-194 (17-802) 
      pg/ml, and Graves' ophthalmopathy patients treated in the past-146 (0-608) pg/ml. 
      No correlation was observed between serum IL-18 levels and thyroid function or 
      antithyroid antibodies. There was no correlation between serum IL-18 levels and 
      smoking habits. CONCLUSION: We conclude that Graves' ophthalmopathy does not 
      affect serum IL-18.
FAU - Wakelkamp, I M M J
AU  - Wakelkamp IM
AD  - Department of Endocrinology, Academic Medical Centre, University of Amsterdam, 
      Amsterdam, The Netherlands. I.M.M.J.Wakelkamp@amc.uva.nl
FAU - Prummel, M F
AU  - Prummel MF
FAU - Wiersinga, W M
AU  - Wiersinga WM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Antithyroid Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Thyroid-Stimulating)
RN  - 0 (Interleukin-18)
RN  - 0 (Receptors, Thyrotropin)
RN  - 0 (thyrotropin-binding inhibitory immunoglobulin)
SB  - IM
MH  - Adult
MH  - Antithyroid Agents/therapeutic use
MH  - Autoantibodies/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graves Disease/*blood/drug therapy
MH  - Humans
MH  - Immunoglobulins, Thyroid-Stimulating
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Receptors, Thyrotropin/blood
MH  - Smoking/blood
EDAT- 2004/02/26 05:00
MHDA- 2004/09/24 05:00
CRDT- 2004/02/26 05:00
PHST- 2004/02/26 05:00 [pubmed]
PHST- 2004/09/24 05:00 [medline]
PHST- 2004/02/26 05:00 [entrez]
AID - 10.1055/s-2004-814102 [doi]
PST - ppublish
SO  - Horm Metab Res. 2004 Jan;36(1):44-7. doi: 10.1055/s-2004-814102.