PMID- 14983933
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20081121
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 121
IP  - 2
DP  - 2004 Feb
TI  - Pulmonary nodular lesions in bone marrow transplant recipients: impact of 
      histologic diagnosis on patient management and prognosis.
PG  - 205-10
AB  - Bone marrow transplantation is associated with numerous pulmonary complications, 
      which may manifest as nodules. We studied 33 bone marrow transplant (BMT) 
      recipients in whom pulmonary nodular lesions (PNLs) developed during a 5-year 
      period and who underwent open lung biopsy (OLB) for diagnosis. Of 33 patients 
      with PNL, 15 (45%) had pulmonary cytolytic thrombi (PCT), a recently described 
      condition characterized histologically by occlusive vascular lesions and 
      hemorrhagic infarcts and clinically by a favorable outcome. Clinical symptoms and 
      radiologic abnormalities disappeared during a period of a few weeks. None of the 
      patients died of PCT; 10 were alive at last contact. The second most common cause 
      of PNL (8/33 [24%]) was Aspergillus infection, which was the cause of death in 6. 
      OLB is an effective way of obtaining diagnostic tissue in BMT recipients with 
      PNLs. Histologic examination is accurate in determining the cause of PNLs and 
      identifying lesions that have a favorable outcome and those that require a change 
      in treatment.
FAU - Gulbahce, H Evin
AU  - Gulbahce HE
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota, 
      Fairview University Medical Center, Minneapolis 55455, USA.
FAU - Pambuccian, Stefan E
AU  - Pambuccian SE
FAU - Jessurun, Jose
AU  - Jessurun J
FAU - Woodard, Paul
AU  - Woodard P
FAU - Steiner, Marie E
AU  - Steiner ME
FAU - Manivel, J Carlos
AU  - Manivel JC
FAU - Hite, Stephen
AU  - Hite S
FAU - Ramsay, Norma K C
AU  - Ramsay NK
FAU - Baker, K Scott
AU  - Baker KS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aspergillosis/complications/*pathology
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunocompromised Host
MH  - Infant
MH  - Lung Diseases, Fungal/complications/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pulmonary Embolism/complications/*pathology
MH  - Solitary Pulmonary Nodule/etiology/*pathology/therapy
EDAT- 2004/02/27 05:00
MHDA- 2004/03/10 05:00
CRDT- 2004/02/27 05:00
PHST- 2004/02/27 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2004/02/27 05:00 [entrez]
AID - 10.1309/4HYN-1DEA-718R-DM6T [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2004 Feb;121(2):205-10. doi: 10.1309/4HYN-1DEA-718R-DM6T.