PMID- 14984925
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20220316
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 25
IP  - 4
DP  - 2004 Feb
TI  - Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with 
      the metabolic syndrome.
PG  - 349-55
AB  - AIMS: Inflammation plays an essential role in the atherosclerotic process, and 
      chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 
      (IL-8) seem to play a pivotal role in the pathogenesis of atherosclerosis. A 
      possible common inflammatory basis for the pathogenesis of type 2 diabetes, 
      metabolic syndrome and atherosclerosis has been suggested. In this study we 
      investigated the effect of physical exercise and the HMG-CoA reductase inhibitor 
      pravastatin on peripheral markers of inflammation in subjects with the metabolic 
      syndrome. METHODS: The study was an unmasked randomized 2x2 factorial trial of 12 
      weeks duration. RESULTS: In the combined exercise groups there was a significant 
      reduction in MCP-1 and IL-8 of 48 pg/ml (P=0.04) and 1.0 pg/ml (P=0.007), 
      respectively, as compared to the combined non-exercise groups. There was also a 
      significant reduction vs baseline of 50 pg/ml (33%) (P=0.002) and 0.35 pg/ml 
      (13%) (P=0.03) for MCP-1 and IL-8, respectively. Changes in MCP-1 were 
      significantly correlated to changes in visceral fat (r=0.41, P=0.02). CONCLUSION: 
      The protective effect of exercise might in part be due to suppression of the 
      inflammatory process.
FAU - Troseid, Marius
AU  - Troseid M
AD  - Department of Medicine, Nordland Hospital, Bodo, Norway.
FAU - Lappegard, Knut T
AU  - Lappegard KT
FAU - Claudi, Tor
AU  - Claudi T
FAU - Damas, Jan K
AU  - Damas JK
FAU - Morkrid, Lars
AU  - Morkrid L
FAU - Brendberg, Randi
AU  - Brendberg R
FAU - Mollnes, Tom E
AU  - Mollnes TE
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/*blood
MH  - *Exercise Therapy
MH  - Humans
MH  - Inflammation
MH  - Interleukin-8/*blood
MH  - Lipids/blood
MH  - Metabolic Syndrome/blood/*rehabilitation
MH  - Middle Aged
EDAT- 2004/02/27 05:00
MHDA- 2004/06/02 05:00
CRDT- 2004/02/27 05:00
PHST- 2003/04/16 00:00 [received]
PHST- 2003/11/13 00:00 [revised]
PHST- 2003/12/04 00:00 [accepted]
PHST- 2004/02/27 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2004/02/27 05:00 [entrez]
AID - S0195668X03008042 [pii]
AID - 10.1016/j.ehj.2003.12.006 [doi]
PST - ppublish
SO  - Eur Heart J. 2004 Feb;25(4):349-55. doi: 10.1016/j.ehj.2003.12.006.