PMID- 1498667
OWN - NLM
STAT- MEDLINE
DCOM- 19920915
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 581
IP  - 1
DP  - 1992 May 22
TI  - An analogue of Joro spider toxin selectively suppresses hippocampal epileptic 
      discharges induced by quisqualate.
PG  - 161-4
AB  - The anticonvulsant effect of 1-naphthylacetyl spermine, an analogue of Joro 
      spider toxin (JSTX), was studied against seizures induced by quisqualate (QUIS), 
      a non-NMDA agonist, as assessed electrophysiologically and behaviorally in freely 
      moving rats. Electrodes were implanted into right dorsal hippocampus and an 
      injection cannula for drugs into right ventricle. The pretreatment with JSTX 
      analogue significantly inhibited both of QUIS-induced hippocampal discharges 
      (80-11%) and generalized tonic clonic seizures (100-33%) in a dose-dependent 
      manner, whereas JSTX had no effect on seizures induced by quinolinate, a NMDA 
      agonist. The paper provides the first direct evidence that the JSTX analogue 
      exerts a potent and selective suppression of hippocampal epileptic discharges 
      mediated by non-N-methyl-D-aspartate (non-NMDA) receptors.
FAU - Kanai, H
AU  - Kanai H
AD  - Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
FAU - Ishida, N
AU  - Ishida N
FAU - Nakajima, T
AU  - Nakajima T
FAU - Kato, N
AU  - Kato N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 122306-11-0 (1-naphthylacetylspermine)
RN  - 2FZ7Y3VOQX (Spermine)
RN  - 8OC22C1B99 (Quisqualic Acid)
SB  - IM
MH  - Animals
MH  - Electroencephalography/drug effects
MH  - Epilepsy/chemically induced/*prevention & control
MH  - Hippocampus/*drug effects
MH  - Male
MH  - Quisqualic Acid/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spermine/*analogs & derivatives/pharmacology
EDAT- 1992/05/22 00:00
MHDA- 1992/05/22 00:01
CRDT- 1992/05/22 00:00
PHST- 1992/05/22 00:00 [pubmed]
PHST- 1992/05/22 00:01 [medline]
PHST- 1992/05/22 00:00 [entrez]
AID - 0006-8993(92)90357-F [pii]
AID - 10.1016/0006-8993(92)90357-f [doi]
PST - ppublish
SO  - Brain Res. 1992 May 22;581(1):161-4. doi: 10.1016/0006-8993(92)90357-f.