PMID- 14987579
OWN - NLM
STAT- MEDLINE
DCOM- 20040622
LR  - 20220310
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 6
IP  - 3
DP  - 2004 Mar 15
TI  - Application of NT-proBNP and BNP measurements in cardiac care: a more discerning 
      marker for the detection and evaluation of heart failure.
PG  - 295-300
AB  - BACKGROUND: Measurement of brain natriuretic peptide (BNP) has become a potent 
      diagnostic aid as a means of identifying patients with systolic or diastolic 
      dysfunction. Due to better stability in circulating blood, we reasoned that 
      measurement of N-terminal proBNP (NT-proBNP) may be a more discerning marker for 
      the detection and evaluation of chronic heart failure. METHODS: The relationships 
      between plasma concentrations of NT-proBNP and BNP, and aetiology, New York Heart 
      Association (NYHA) classification, and left ventricular ejection fraction (LVEF) 
      were analyzed in 105 patients with chronic heart failure. Sixty-seven healthy 
      volunteers were studied as the controls. RESULTS: Both NT-proBNP and BNP showed 
      progressive increases (P<0.001) in proportion to the NYHA classification; the 
      increment of NT-proBNP was larger than that of BNP. Elevated NT-proBNP 
      significantly correlated with BNP (r=0.737, P<0.001). Receiver operating 
      characteristics analysis to detect LVEF<40% showed similar values (area under the 
      curve, AUC: NT-proBNP 0.754 vs. BNP 0.770), however, AUC to detect LVEF<50% 
      tended to be greater for NT-proBNP than that for BNP (NT-proBNP 0.820 vs. BNP 
      0.794). CONCLUSION: NT-proBNP may be a more discerning marker for the detection 
      and evaluation of heart failure than BNP.
FAU - Seino, Yoshihiko
AU  - Seino Y
AD  - The First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, 
      Tokyo, Japan. y-seino@nms.ac.jp
FAU - Ogawa, Akio
AU  - Ogawa A
FAU - Yamashita, Teruyo
AU  - Yamashita T
FAU - Fukushima, Masato
AU  - Fukushima M
FAU - Ogata, Ken-ichi
AU  - Ogata K
FAU - Fukumoto, Hiroko
AU  - Fukumoto H
FAU - Takano, Teruo
AU  - Takano T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Female
MH  - Heart Failure/blood/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/biosynthesis/*blood
MH  - Nerve Tissue Proteins/biosynthesis/*blood
MH  - Peptide Fragments/biosynthesis/*blood
MH  - Predictive Value of Tests
MH  - Ventricular Dysfunction/blood/metabolism
EDAT- 2004/02/28 05:00
MHDA- 2004/06/23 05:00
CRDT- 2004/02/28 05:00
PHST- 2003/11/30 00:00 [received]
PHST- 2003/12/22 00:00 [accepted]
PHST- 2004/02/28 05:00 [pubmed]
PHST- 2004/06/23 05:00 [medline]
PHST- 2004/02/28 05:00 [entrez]
AID - S1388984204000054 [pii]
AID - 10.1016/j.ejheart.2003.12.009 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2004 Mar 15;6(3):295-300. doi: 10.1016/j.ejheart.2003.12.009.