PMID- 14987969
OWN - NLM
STAT- MEDLINE
DCOM- 20040701
LR  - 20151119
IS  - 0022-3999 (Print)
IS  - 0022-3999 (Linking)
VI  - 56
IP  - 1
DP  - 2004 Jan
TI  - Heart rate variability increases in elderly depressed patients who respond to 
      electroconvulsive therapy.
PG  - 89-94
AB  - OBJECTIVES: To evaluate the parasympathetic modulation in elderly inpatients with 
      major depressive disorder (MDD) before and after electroconvulsive therapy (ECT) 
      using both linear and nonlinear methods of heart rate variability (HRV) analysis. 
      METHOD: A measure of local dimensional complexity (pointwise correlation 
      dimension, PD2), as well as spectral analysis measures (LF, low-frequency range; 
      HF, high-frequency range) were calculated for the heart rate time series of 10 
      elderly inpatients with MDD (70+/-7 years) before and after ECT. Hamilton 
      Depression Rating Scale (HAM-D) was evaluated concomitantly. RESULTS: Only the 
      responders to ECT (n=7; >or=50% reduction in HAM-D) exhibited a significant 
      increase in PD2 (P=.0035), which showed a tendency towards a correlation with 
      symptom improvement (r=.73, P=.06). Spectral analysis measures did not show a 
      significant difference after ECT. CONCLUSION: Elderly patients with MDD, who 
      respond to ECT, might show increased vagal modulation. Since nonlinear HRV 
      measures have been shown to be reduced by aging, similar to cholinergic deficit, 
      they might shed light on the increased risk for cardiac mortality in depression.
FAU - Nahshoni, Eitan
AU  - Nahshoni E
AD  - Department of Cardiology, Rabin Medical Center, Petach Tikva, Israel. 
      green175@netvision.net.il
FAU - Aizenberg, Dov
AU  - Aizenberg D
FAU - Sigler, Mayanit
AU  - Sigler M
FAU - Strasberg, Boris
AU  - Strasberg B
FAU - Zalsman, Gil
AU  - Zalsman G
FAU - Imbar, Shula
AU  - Imbar S
FAU - Adler, Edgar
AU  - Adler E
FAU - Weizman, Abraham
AU  - Weizman A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Depressive Disorder, Major/diagnosis/*physiopathology/*therapy
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Electrocardiography
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2004/02/28 05:00
MHDA- 2004/07/02 05:00
CRDT- 2004/02/28 05:00
PHST- 2002/05/29 00:00 [received]
PHST- 2002/11/01 00:00 [accepted]
PHST- 2004/02/28 05:00 [pubmed]
PHST- 2004/07/02 05:00 [medline]
PHST- 2004/02/28 05:00 [entrez]
AID - S0022399903000370 [pii]
AID - 10.1016/S0022-3999(03)00037-0 [doi]
PST - ppublish
SO  - J Psychosom Res. 2004 Jan;56(1):89-94. doi: 10.1016/S0022-3999(03)00037-0.