PMID- 14989713
OWN - NLM
STAT- MEDLINE
DCOM- 20040928
LR  - 20101118
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 3
DP  - 2004 Mar
TI  - Genes in the HLA class I region may contribute to the HLA class II-associated 
      genetic susceptibility to multiple sclerosis.
PG  - 237-47
AB  - In order to analyze whether loci in the human leukocyte antigen (HLA) class I 
      region may contribute to the HLA class II-associated genetic susceptibility to 
      multiple sclerosis (MS), we examined selected microsatellite markers in 177 
      Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian 
      MS patients and 386 Norwegian controls. All samples were, in addition, genotyped 
      for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also 
      typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association 
      was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb 
      centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested 
      when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a 
      similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) 
      was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to 
      those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these 
      alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 
      and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in 
      linkage disequilibrium with it may contribute to the HLA class II-associated 
      genetic susceptibility to MS.
FAU - Harbo, H F
AU  - Harbo HF
AD  - Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway.
FAU - Lie, B A
AU  - Lie BA
FAU - Sawcer, S
AU  - Sawcer S
FAU - Celius, E G
AU  - Celius EG
FAU - Dai, K-Z
AU  - Dai KZ
FAU - Oturai, A
AU  - Oturai A
FAU - Hillert, J
AU  - Hillert J
FAU - Lorentzen, A R
AU  - Lorentzen AR
FAU - Laaksonen, M
AU  - Laaksonen M
FAU - Myhr, K-M
AU  - Myhr KM
FAU - Ryder, L P
AU  - Ryder LP
FAU - Fredrikson, S
AU  - Fredrikson S
FAU - Nyland, H
AU  - Nyland H
FAU - Sorensen, P S
AU  - Sorensen PS
FAU - Sandberg-Wollheim, M
AU  - Sandberg-Wollheim M
FAU - Andersen, O
AU  - Andersen O
FAU - Svejgaard, A
AU  - Svejgaard A
FAU - Edland, A
AU  - Edland A
FAU - Mellgren, S I
AU  - Mellgren SI
FAU - Compston, A
AU  - Compston A
FAU - Vartdal, F
AU  - Vartdal F
FAU - Spurkland, A
AU  - Spurkland A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Genetic Markers)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Case-Control Studies
MH  - Europe
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Multiple Sclerosis/etiology/*genetics
EDAT- 2004/03/03 05:00
MHDA- 2004/09/29 05:00
CRDT- 2004/03/03 05:00
PHST- 2004/03/03 05:00 [pubmed]
PHST- 2004/09/29 05:00 [medline]
PHST- 2004/03/03 05:00 [entrez]
AID - TAN173 [pii]
AID - 10.1111/j.0001-2815.2004.00173.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Mar;63(3):237-47. doi: 10.1111/j.0001-2815.2004.00173.x.