PMID- 14989805
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20190917
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 8
IP  - 2
DP  - 2004 Feb
TI  - Thirteen years' experience of preimplantation diagnosis: report of the Fifth 
      International Symposium on Preimplantation Genetics.
PG  - 229-35
AB  - Preimplantation genetic diagnosis (PGD) has been further developed into a 
      practical option for avoiding the birth of affected children, representing an 
      important complement to traditional prenatal diagnosis. More than 1000 unaffected 
      children have been born after PGD, suggesting the accuracy and safety of the 
      procedure, which is currently also used with the establishment of potential donor 
      progeny for stem cell treatment of siblings. Together with progress in the 
      establishment of embryonic stem (ES) cells, this may contribute to the 
      development and application of stem cell therapy. The accumulated experience of 
      thousands of PGD cycles for poor prognosis IVF patients provides further evidence 
      of the improvement of clinical outcome, particularly obvious from the 
      reproductive history of PGD patients. A high prevalence of aneuploidies in 
      oocytes and embryos may affect the accuracy of PGD for single gene disorders, 
      making aneuploidy testing an important part of PGD for causative genes and 
      preimplantation human leukocyte antigen (HLA) typing. A sequential sampling of 
      both oocytes and the resulting embryos may improve accuracy of aneuploidy testing 
      and may also allow the detection and avoidance of transfer of embryos with 
      uniparental disomies. Current developments and application of nuclear transfer 
      and sperm duplication techniques, and microarray technology, may also contribute 
      to the improvement of PGD and help in the development of PGD for genetic 
      expression disorders.
FAU - Kuliev, Anver
AU  - Kuliev A
AD  - Reproductive Genetics Institute, Chicago, IL, USA.
FAU - Verlinsky, Yury
AU  - Verlinsky Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Female
MH  - Genetic Diseases, Inborn/*genetics
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Preimplantation Diagnosis
MH  - Stem Cell Transplantation
EDAT- 2004/03/03 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/03/03 05:00
PHST- 2004/03/03 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/03/03 05:00 [entrez]
AID - S1472-6483(10)60521-4 [pii]
AID - 10.1016/s1472-6483(10)60521-4 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2004 Feb;8(2):229-35. doi: 10.1016/s1472-6483(10)60521-4.