PMID- 14993187
OWN - NLM
STAT- MEDLINE
DCOM- 20040503
LR  - 20040302
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 131
IP  - 6
DP  - 2004 Mar
TI  - Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory 
      receptor neuron projection.
PG  - 1377-88
AB  - The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) 
      transcription factors has been implicated in olfactory system gene regulation, 
      nervous system development and B-cell differentiation. Ebf (O/E1) mutant animals 
      showed defects in B-cell lineage and brain regions where it is the only O/E 
      family member expressed, but the olfactory epithelium appeared unaffected and 
      olfactory marker expression was grossly normal in these animals. In order to 
      further study the mammalian O/E proteins, we disrupted O/E2 and O/E3 genes in 
      mouse and placed tau-lacZ and tau-GFP reporter genes under the control of the 
      respective endogenous O/E promoters. Mice mutant for each of these genes display 
      reduced viability and other gene-specific phenotypes. Interestingly, both O/E2 
      and O/E3 knockout mice as well as O/E2/O/E3 double heterozygous animals share a 
      common phenotype: olfactory neurons (ORN) fail to project to dorsal olfactory 
      bulb. We suggest that a decreased dose of O/E protein may alter expression of O/E 
      target genes and underlie the ORN projection defect.
FAU - Wang, Song S
AU  - Wang SS
AD  - The Howard Hughes Medical Institute, The Johns Hopkins University School of 
      Medicine, 725 North Wolfe Street, PCTB 818, Baltimore, MD 21205, USA.
FAU - Lewcock, Joseph W
AU  - Lewcock JW
FAU - Feinstein, Paul
AU  - Feinstein P
FAU - Mombaerts, Peter
AU  - Mombaerts P
FAU - Reed, Randall R
AU  - Reed RR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Receptors, Odorant)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Genes, Reporter
MH  - Mice
MH  - Olfactory Receptor Neurons/cytology/*metabolism
MH  - Phenotype
MH  - Receptors, Odorant/metabolism
MH  - Recombinant Fusion Proteins
MH  - Transcription Factors/deficiency/*genetics/metabolism
MH  - tau Proteins/genetics/metabolism
EDAT- 2004/03/03 05:00
MHDA- 2004/05/05 05:00
CRDT- 2004/03/03 05:00
PHST- 2004/03/03 05:00 [pubmed]
PHST- 2004/05/05 05:00 [medline]
PHST- 2004/03/03 05:00 [entrez]
AID - 131/6/1377 [pii]
AID - 10.1242/dev.01009 [doi]
PST - ppublish
SO  - Development. 2004 Mar;131(6):1377-88. doi: 10.1242/dev.01009.