PMID- 14993460
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20161019
IS  - 1534-0384 (Print)
IS  - 1534-0384 (Linking)
VI  - 3
IP  - 7
DP  - 2003 Oct
TI  - CaMKII, an enzyme on the move: regulation of temporospatial localization.
PG  - 386-403
AB  - Calcium-calmodulin-dependent protein kinase II (CaMKII) is an important regulator 
      of neuronal and behavioral plasticity. Studies in which the subcellular 
      distribution of CaMKII has been altered argue that targeting of this enzyme to 
      specific subcellular compartments is crucial to many of its roles. Understanding 
      how a very abundant enzyme can achieve specificity of action over time and space 
      requires an understanding of the functional diversity of the enzyme and its 
      distribution. In this review we will discuss how structurally distinct isozymes, 
      splice isoforms, and autophosphorylation states of CaMKII can affect kinase 
      activity and localization. We will focus on the fast activity-dependent synaptic 
      localization of the kinase and its association with postsynaptic proteins. The 
      ability of enzyme activation to regulate protein-protein interactions with these 
      binding partners and the potential for such binding interactions to regulate 
      CaMKII activity in novel ways may represent new paradigm for CaMKII regulation.
FAU - Griffith, Leslie C
AU  - Griffith LC
AD  - Department of Biology and Volen Center for Complex Systems, Brandeis University, 
      415 South St., Waltham, MA 02454-9110, USA.
FAU - Lu, Cecilia S
AU  - Lu CS
FAU - Sun, Xiu Xia
AU  - Sun XX
LA  - eng
GR  - R01 GM054408/GM/NIGMS NIH HHS/United States
GR  - GM54408/GM/NIGMS NIH HHS/United States
GR  - MH067284/MH/NIMH NIH HHS/United States
GR  - NS44232/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Mol Interv
JT  - Molecular interventions
JID - 101093789
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/genetics/*metabolism
MH  - Humans
MH  - Muscles/cytology/enzymology
MH  - Protein Binding
MH  - Protein Transport
MH  - Sarcoplasmic Reticulum/enzymology
MH  - Synapses/enzymology/metabolism
RF  - 108
EDAT- 2004/03/03 05:00
MHDA- 2004/04/24 05:00
CRDT- 2004/03/03 05:00
PHST- 2004/03/03 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2004/03/03 05:00 [entrez]
AID - 3/7/386 [pii]
AID - 10.1124/mi.3.7.386 [doi]
PST - ppublish
SO  - Mol Interv. 2003 Oct;3(7):386-403. doi: 10.1124/mi.3.7.386.