PMID- 14998723
OWN - NLM
STAT- MEDLINE
DCOM- 20041012
LR  - 20041117
IS  - 0009-3084 (Print)
IS  - 0009-3084 (Linking)
VI  - 129
IP  - 1
DP  - 2004 Apr
TI  - Sphingolipids in human lens membranes: an update on their composition and 
      possible biological implications.
PG  - 1-20
AB  - The unique nature of the most abundant phospholipids in human lens membranes 
      remained overlooked until the 1990s when it was possible to discern 
      dihydrosphingomyelins (DHSMs) from the more common sphingomyelins (SMs). Unlike 
      in other mammalian membranes, DHSMs comprise nearly half of the phospholipids in 
      adult human lenses. Compared to SMs with a trans double bond between carbons 4 
      and 5 of the sphingoid backbone, the absence of this unsaturation site in DHSMs 
      allows the participation of the OH group on C3 in intermolecular H-bonds and 
      leads to stronger interlipid interactions with both neighboring DHSMs and 
      cholesterol. Phospholipid compositional changes with age and lens region observed 
      in mammals with various life spans and lens growth rates, suggest that the 
      highest levels of DHSMs along with the lowest amounts of phosphatidylcholines and 
      SMs are found in lenses with the lowest growth rate, namely human lenses. The 
      participation of phospholipid metabolites in the control of mitosis and 
      elongation of lens cells is plausible and deserves investigation.
FAU - Yappert, M Cecilia
AU  - Yappert MC
AD  - Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. 
      mcyappert@louisville.edu
FAU - Borchman, Douglas
AU  - Borchman D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (4,5-dihydrosphingomyelin)
RN  - 0 (Phosphatidylcholines)
RN  - 0 (Sphingolipids)
RN  - 0 (Sphingomyelins)
SB  - IM
MH  - Adult
MH  - Aging/physiology
MH  - Cell Membrane/*chemistry/metabolism
MH  - Humans
MH  - Lens, Crystalline/*chemistry/growth & development/metabolism
MH  - Phosphatidylcholines/chemistry/metabolism
MH  - Sphingolipids/*chemistry/*metabolism
MH  - Sphingomyelins/chemistry/metabolism
RF  - 239
EDAT- 2004/03/05 05:00
MHDA- 2004/10/13 09:00
CRDT- 2004/03/05 05:00
PHST- 2003/11/18 00:00 [received]
PHST- 2003/12/13 00:00 [revised]
PHST- 2003/12/15 00:00 [accepted]
PHST- 2004/03/05 05:00 [pubmed]
PHST- 2004/10/13 09:00 [medline]
PHST- 2004/03/05 05:00 [entrez]
AID - S0009308403001968 [pii]
AID - 10.1016/j.chemphyslip.2003.12.003 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2004 Apr;129(1):1-20. doi: 10.1016/j.chemphyslip.2003.12.003.