PMID- 14999597
OWN - NLM
STAT- MEDLINE
DCOM- 20040408
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 6
DP  - 2004 Mar 15
TI  - Extended human leukocyte antigen haplotype EH18.1 influences progression to 
      hepatocellular carcinoma in patients with hepatitis C virus infection.
PG  - 957-63
AB  - Our aim was to investigate whether different human leukocyte antigen (HLA) genes 
      might be associated with hepatitis C virus (HCV) infection. DNA obtained from 141 
      Spanish patients with HCV infection (48 with alanine aminotransferase levels in 
      the range considered to be normal, 47 with liver cirrhosis, and 46 with 
      hepatocellular carcinomas [HCCs]) and from 116 control subjects were typed for 
      HLA-B, HLA-DRB1, and HLA-DQB1 alleles, as well as for major histocompatibility 
      complex class I chain-related gene A (MICA) transmembrane polymorphism. The 
      frequency of HLA-DR11 was increased in HCV carriers, compared with patients with 
      end-stage liver disease (ESLD) (corrected P value [Pc],.0002) and, especially, 
      with patients who had HCC (Pc=.003). The frequency of the HLA-B18 allele was 
      increased in patients with HCC, and the allele was absent in HCV carriers 
      (Pc=.003). The MICA-A4 allele was overrepresented in patients with HCC, compared 
      with HCV carriers (Pc=.0002). The DR3/MICA-A4/B18 haplotype was associated with 
      HCC (Pc=.01). In conclusion, HLA-DR11 seems to be protective against the 
      development of severe forms of infection, and the DR3/MICA-A4/B18 haplotype may 
      be an important factor in the progression to the most severe HCV-infection 
      status.
FAU - Lopez-Vazquez, Antonio
AU  - Lopez-Vazquez A
AD  - Department of Immunology, Hospital Central de Asturias, Oviedo, Spain.
FAU - Rodrigo, Luis
AU  - Rodrigo L
FAU - Mina-Blanco, Agustin
AU  - Mina-Blanco A
FAU - Martinez-Borra, Jesus
AU  - Martinez-Borra J
FAU - Fuentes, Dolores
AU  - Fuentes D
FAU - Rodriguez, Manuel
AU  - Rodriguez M
FAU - Perez, Ramon
AU  - Perez R
FAU - Gonzalez, Segundo
AU  - Gonzalez S
FAU - Lopez-Larrea, Carlos
AU  - Lopez-Larrea C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040302
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Carcinoma, Hepatocellular/*etiology
MH  - Disease Progression
MH  - Female
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/*genetics
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Liver Neoplasms/*etiology
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 2004/03/05 05:00
MHDA- 2004/04/09 05:00
CRDT- 2004/03/05 05:00
PHST- 2003/02/10 00:00 [received]
PHST- 2003/09/17 00:00 [accepted]
PHST- 2004/03/05 05:00 [pubmed]
PHST- 2004/04/09 05:00 [medline]
PHST- 2004/03/05 05:00 [entrez]
AID - JID30681 [pii]
AID - 10.1086/382189 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Mar 15;189(6):957-63. doi: 10.1086/382189. Epub 2004 Mar 2.