PMID- 14999612
OWN - NLM
STAT- MEDLINE
DCOM- 20040408
LR  - 20111117
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 6
DP  - 2004 Mar 15
TI  - Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte 
      antigen variation.
PG  - 1084-90
AB  - Genetic variation influences immune responses and may contribute to differential 
      development of tuberculosis (TB), particularly in immunosuppressed individuals. 
      To examine the risk of Mycobacterium tuberculosis infection progressing to 
      disease in the context of M. tuberculosis/human immunodeficiency virus (HIV) type 
      1 coinfection, HIV-1 RNA load and human leukocyte antigen (HLA) genotypes were 
      determined among subjects from Harare, Zimbabwe, an area where both TB and HIV-1 
      are endemic. Patients with TB were compared with control subjects, stratified by 
      HIV-1 infection status and progression of TB disease. Alleles of class I HLA-A 
      and -C were associated with risk of developing active TB, depending on HIV-1 
      status. Among HIV-positive subjects, HIV-1 load was independently associated with 
      increased risk of developing pulmonary TB. HLA DRB1 homozygosity among 
      HIV-positive subjects was associated with reduced risk of developing pulmonary TB 
      but increased risk of rapid progression to pleural effusion TB. These 
      observations suggest that HLA plays a role in risk of developing symptomatic TB 
      at various stages of disease and that these effects are modified by HIV-1 
      coinfection.
FAU - Louie, Leslie G
AU  - Louie LG
AD  - Research Department, Children's Hospital and Research Center at Oakland, 
      California 94609-1673, USA. llouie@chori.org
FAU - Hartogensis, Wendy E
AU  - Hartogensis WE
FAU - Jackman, Rachael P
AU  - Jackman RP
FAU - Schultz, Kathleen A
AU  - Schultz KA
FAU - Zijenah, Lynn S
AU  - Zijenah LS
FAU - Yiu, Carina H-Y
AU  - Yiu CH
FAU - Nguyen, Viet D
AU  - Nguyen VD
FAU - Sohsman, Marie Y
AU  - Sohsman MY
FAU - Katzenstein, David K
AU  - Katzenstein DK
FAU - Mason, Peter R
AU  - Mason PR
LA  - eng
GR  - 1 R01 AI 40019/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040227
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/complications/genetics/*immunology
MH  - Adult
MH  - Alleles
MH  - Female
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - *HIV-1
MH  - HLA-A Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Tuberculosis/complications/genetics/*immunology
EDAT- 2004/03/05 05:00
MHDA- 2004/04/09 05:00
CRDT- 2004/03/05 05:00
PHST- 2003/05/05 00:00 [received]
PHST- 2003/09/08 00:00 [accepted]
PHST- 2004/03/05 05:00 [pubmed]
PHST- 2004/04/09 05:00 [medline]
PHST- 2004/03/05 05:00 [entrez]
AID - JID31068 [pii]
AID - 10.1086/382030 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Mar 15;189(6):1084-90. doi: 10.1086/382030. Epub 2004 Feb 27.