PMID- 14999936
OWN - NLM
STAT- MEDLINE
DCOM- 20040421
LR  - 20071115
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 45
IP  - 1
DP  - 2004 Jan
TI  - [FISH detected 11q23 microdeletion and translocation at the long arm of 
      chromosome 11 in a child with normal karyotypic acute lymphoblastic leukemia].
PG  - 61-5
AB  - We report on a 6-year-old girl with acute lymphoblastic leukemia (ALL) with 11q23 
      microdeletion and translocation at the long arm of chromosome 11, which were 
      detected by fluorescence in situ hybridization (FISH) but not by conventional 
      cytogenetics. She was hospitalized because of fever and generalized bone pain. 
      Results of peripheral blood examination included a WBC of 5,400/microliter with 
      12% lymphoblasts. Bone marrow studies showed 75% of early pre-B lineage 
      lymphoblasts with L1 morphology. G-banding chromosome analysis demonstrated a 
      normal karyotype. However, FISH using mixed lineage leukemia (MLL) and 11q 
      subtelomere probes demonstrated 11q23 microdeletion and translocation at the long 
      arm of chromosome 11 to an undefined chromosome. MLL rearrangement was not 
      detected by Southern blotting analysis. The patient achieved complete remission 
      15 days after receiving high-risk group chemotherapy of the Kyoto University 
      Pediatric Hematology/Oncology Study Group and has remained in complete remission 
      for more than 30 months. Since MLL/11q23 abnormalities confer a poor prognosis in 
      childhood ALL, the accurate detection of such abnormalities is of paramount 
      significance in assigning individual cases to risk categories. The findings from 
      the present case and recent literature indicate that the FISH-based approach is 
      complementary to conventional cytogenetics, and should be systematically used in 
      childhood ALL at diagnosis.
FAU - Matsubara, Kousaku
AU  - Matsubara K
AD  - Department of Pediatrics, Nishi-Kobe Medical Center.
FAU - Yura, Kazuo
AU  - Yura K
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Child
MH  - *Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 11
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics
MH  - Remission Induction
MH  - Risk
EDAT- 2004/03/06 05:00
MHDA- 2004/04/22 05:00
CRDT- 2004/03/06 05:00
PHST- 2004/03/06 05:00 [pubmed]
PHST- 2004/04/22 05:00 [medline]
PHST- 2004/03/06 05:00 [entrez]
PST - ppublish
SO  - Rinsho Ketsueki. 2004 Jan;45(1):61-5.