PMID- 15001163
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20071114
IS  - 1044-579X (Print)
IS  - 1044-579X (Linking)
VI  - 13
IP  - 6
DP  - 2003 Dec
TI  - Dendritic cells as vectors for immunotherapy of cancer.
PG  - 439-47
AB  - Dendritic cells (DCs) initiate and regulate immune responses. Numerous studies in 
      mice showed that tumor antigens-loaded DCs are able to induce therapeutic and 
      protective anti-tumor immunity. The immunogenicity of antigens delivered on DCs 
      has now been demonstrated in cancer patients and some clinical responses without 
      any significant toxicity have been observed. Nevertheless, many parameters of DC 
      vaccination need to be established including: (1) the type of DCs, their 
      maturation stage and stimuli; (2) the quality and the breadth of induced immune 
      responses; (3) host-related factors, such as the extent of metastatic disease and 
      myeloablation; and (4) efficacy as measured by the clinical outcome.
FAU - Paczesny, Sophie
AU  - Paczesny S
AD  - Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA.
FAU - Ueno, Hideki
AU  - Ueno H
FAU - Fay, Joseph
AU  - Fay J
FAU - Banchereau, Jacques
AU  - Banchereau J
FAU - Palucka, A Karolina
AU  - Palucka AK
LA  - eng
GR  - CA085540-03/CA/NCI NIH HHS/United States
GR  - CA78846/CA/NCI NIH HHS/United States
GR  - CA84990-03/CA/NCI NIH HHS/United States
GR  - P0-1 CA84512/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/*immunology
MH  - Cancer Vaccines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Neoplasms/immunology/therapy
MH  - Vaccination
RF  - 100
EDAT- 2004/03/06 05:00
MHDA- 2004/07/14 05:00
CRDT- 2004/03/06 05:00
PHST- 2004/03/06 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2004/03/06 05:00 [entrez]
AID - S1044579X03000750 [pii]
AID - 10.1016/j.semcancer.2003.09.008 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 2003 Dec;13(6):439-47. doi: 10.1016/j.semcancer.2003.09.008.